USP47

USP47

Identifiers

USP47, TRFP, ubiquitin specific peptidase 47

External IDs

OMIM: 614460; MGI: 1922246; GeneCards: USP47

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.4.19.12	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11p15.3	Start	11,841,423 bp
Band	11p15.3	End	11,959,323 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 F1	Start	111,622,711 bp
Band	7\|7 F1	End	111,710,868 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

internal globus pallidus

endothelial cell

glutes

secondary oocyte

seminal vesicula

vena cava

corpus callosum

biceps brachii

periodontal fiber

Top expressed in

ciliary body

vastus lateralis muscle

triceps brachii muscle

spermatid

gastrocnemius muscle

tibialis anterior muscle

medial head of gastrocnemius muscle

ankle

spermatocyte

muscle of thigh

More reference expression data


More reference expression data

Gene ontology
Molecular function	WD40-repeat domain binding peptidase activity hydrolase activity cysteine-type peptidase activity thiol-dependent deubiquitinase protein binding deubiquitinase activity cysteine-type endopeptidase activity
Cellular component	cytoplasm SCF ubiquitin ligase complex nucleoplasm cytosol
Biological process	ubiquitin-dependent protein catabolic process proteolysis negative regulation of apoptotic process cellular response to UV negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage DNA repair positive regulation of cell growth monoubiquitinated protein deubiquitination base-excision repair negative regulation of G2/M transition of mitotic cell cycle negative regulation of transcription, DNA-templated negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus protein deubiquitination positive regulation of canonical Wnt signaling pathway regulation of protein stability
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55031


74996


ENSG00000170242


ENSMUSG00000059263


Q96K76


Q8BY87

RefSeq (mRNA)


NM_001282659 NM_017944 NM_001330208


NM_133758 NM_177249 NM_001357952

RefSeq (protein)

NP_001269588 NP_001317137 NP_060414 NP_001359020 NP_001359021
NP_001359022 NP_001359023 NP_001359024 NP_001359025 NP_001359026 NP_001359027 NP_001359028 NP_001359029 NP_001359030 NP_001359031 NP_001359032


NP_598519 NP_796223 NP_001344881 NP_001390423

Location (UCSC)

Chr 11: 11.84 – 11.96 Mb

Chr 7: 111.62 – 111.71 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170242 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059263 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ "Entrez Gene: USP47 ubiquitin specific peptidase 47".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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