USS Colossus may refer to the following ships of the United States Navy:
- USS Colossus (1864), a steamer which served during the American Civil War
- USS Colossus (1869), a monitor, which was renamed from Kalamazoo on 15 June 1869
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.