USS Mugford may refer to the following ships of the United States Navy:
- USS Mugford (DD-105), Wickes-class destroyer that was launched in 1918 and decommissioned in 1922
- USS Mugford (DD-389), Bagley-class destroyer that was launched in 1937 and served until 1947, having served through World War II
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.