SNF8

SNF8

Identifiers

SNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II

External IDs

OMIM: 610904; MGI: 1343161; GeneCards: SNF8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2ZME, 3CUQ

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q21.32	Start	48,929,316 bp
Band	17q21.32	End	48,944,842 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11 D\|11 59.24 cM	Start	95,925,711 bp
Band	11 D\|11 59.24 cM	End	95,938,256 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

apex of heart

mucosa of transverse colon

gastric mucosa

stromal cell of endometrium

left coronary artery

ganglionic eminence

right auricle of heart

right adrenal gland

popliteal artery

tibial arteries

Top expressed in

embryo

yolk sac

morula

dentate gyrus of hippocampal formation granule cell

epiblast

blastocyst

right kidney

superior frontal gyrus

facial motor nucleus

duodenum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein homodimerization activity protein N-terminus binding transcription factor binding protein C-terminus binding channel regulator activity protein binding
Cellular component	cytoplasm recycling endosome cytosol endosome membrane late endosome membrane transcription regulator complex plasma membrane nucleoplasm perinuclear region of cytoplasm endosome membrane extracellular exosome nucleus ESCRT II complex
Biological process	regulation of transcription, DNA-templated positive regulation of protein catabolic process multivesicular body sorting pathway regulation of transcription by RNA polymerase II multivesicular body assembly regulation of multivesicular body size involved in endosome transport transcription, DNA-templated endosomal transport regulation of protein complex stability positive regulation of gene expression early endosome to late endosome transport endocytic recycling regulation of protein catabolic process protein transport regulation of MAP kinase activity positive regulation of exosomal secretion protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macroautophagy regulation of molecular function transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


11267


27681


ENSG00000159210


ENSMUSG00000006058


Q96H20


Q9CZ28

RefSeq (mRNA)


NM_007241 NM_001317192 NM_001317193 NM_001317194


NM_033568 NM_001356362

RefSeq (protein)


NP_001304121 NP_001304122 NP_001304123 NP_009172


NP_291046 NP_001343291

Location (UCSC)

Chr 17: 48.93 – 48.94 Mb

Chr 11: 95.93 – 95.94 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene. It is a part of ESCRT-II complex.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159210 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006058 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schmidt AE; Miller T; Schmidt SL; Shiekhattar R; Shilatifard A (Aug 1999). "Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II". J Biol Chem. 274 (31): 21981–5. doi:10.1074/jbc.274.31.21981. PMID 10419521.
↑ Hierro A; Sun J; Rusnak AS; Kim J; Prag G; Emr SD; Hurley JH (Sep 2004). "Structure of the ESCRT-II endosomal trafficking complex". Nature. 431 (7005): 221–5. Bibcode:2004Natur.431..221H. doi:10.1038/nature02914. PMID 15329733. S2CID 4332050.
↑ "SNF8 SNF8 subunit of ESCRT-II [ Homo sapiens (human) ]".

Further reading

Kamura T, Burian D, Khalili H, et al. (2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J. Biol. Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
Langelier C, von Schwedler UK, Fisher RD, et al. (2006). "Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release". J. Virol. 80 (19): 9465–80. doi:10.1128/JVI.01049-06. PMC 1617254. PMID 16973552.

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