Varghese is a Syriac–Malayalam form of the Assyrian Syriac/Aramaic Christian name Giwargis, the Syriac equivalent of George.
The related Malayalam variants include Varughese, Verghese, Geevarghese, Varughis, and Varkey. It is given as first, middle, or last name among the Syrian Christians, an ancient community of Christians from Kerala, India.
The pronunciation from Syriac/Aramaic was naturally adapted to fit the vowels of the local dialect. Many names of this community are a combination of Aramaic and Hebrew names, that have been adapted into the local dialect.