WDR4

WDR4
Identifiers
Aliases	WDR4, TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho
External IDs	OMIM: 605924; MGI: 1889002; GeneCards: WDR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CKK
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,879,568 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,738,954 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; mucosa of transverse colon; ; gonad; ; gastrocnemius muscle; ; pancreatic ductal cell; ; testicle; ; stromal cell of endometrium; ; body of pancreas; ; vagina; ; ganglionic eminence;
	Top expressed in
	epiblast; ; yolk sac; ; embryo; ; embryo; ; ventricular zone; ; primitive streak; ; granulocyte; ; lens; ; morula; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA (guanine-N7-)-methyltransferase activity; protein binding;
Cellular component	nucleoplasm; nucleus; cytosol; tRNA methyltransferase complex;
Biological process	RNA (guanine-N7)-methylation; tRNA modification; tRNA processing; tRNA (guanine-N7)-methylation; tRNA methylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10785
	57773
	ENSG00000160193
	ENSMUSG00000024037
	P57081
	Q9EP82
NM_001260474; NM_001260475; NM_001260476; NM_001260477; NM_018669;
	NM_033661
	NM_021322
NP_001247403; NP_001247404; NP_001247405; NP_001247406; NP_061139;
	NP_387510
	NP_067297
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene. This protein is a non-enzyme subunit of the METTL1-WDR4 complex which acts as a methyltransferase that produces N7-methylguanine in RNAs like tRNAs, mRNAs and microRNAs. In this complex, WDR4 functions as a scaffold for binding with tRNA.

Structure/family

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

Medical significance

Pathogenic mutations in WDR4 have been associated with defects in brain development. Two separate forms have been observed, designated Galloway-Mowat syndrome-6 (GAMOS6) and microcephaly, growth deficiency, seizures, and brain malformations (MIGSB). Both appear to follow an autosomal recessive inheritance pattern.

This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160193 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024037 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Entrez Gene: WDR4 WD repeat domain 4".
1 2 "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4". UniProt consortium. Retrieved 2026-11-01.
1 2 Chang YC, Kniffin CL (2019-03-08). "WD REPEAT-CONTAINING PROTEIN 4; WDR4". OMIM. Johns Hopkins university. Retrieved 2026-11-01.

Michaud J, Kudoh J, Berry A, et al. (2001). "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein". Genomics. 68 (1): 71–9. doi:10.1006/geno.2000.6258. PMID 10950928.
Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10) S1355838202024019: 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160193 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024037 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "Entrez Gene: WDR4 WD repeat domain 4".

[uniprot-6] 1 2 "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4". UniProt consortium. Retrieved 2026-11-01.

[omim-7] 1 2 Chang YC, Kniffin CL (2019-03-08). "WD REPEAT-CONTAINING PROTEIN 4; WDR4". OMIM. Johns Hopkins university. Retrieved 2026-11-01.

WDR4

Structure/family

Medical significance

References

Further reading