WDR73

WDR73
Identifiers
Aliases	WDR73, GAMOS, HSPC264, WD repeat domain 73, GAMOS1
External IDs	OMIM: 616144; MGI: 1919218; GeneCards: WDR73
Gene location (Human)
Chr.	Chromosome 15 (human)
End	84,654,343 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,551,017 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; pituitary gland; ; anterior pituitary; ; epithelium of bronchus; ; bronchial epithelial cell; ; left lobe of thyroid gland; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	otic vesicle; ; hand; ; epiblast; ; morula; ; embryo; ; ventricular zone; ; embryo; ; blastocyst; ; neural tube; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	cytoplasm; spindle; cytoskeleton; spindle pole; cytosol; cleavage furrow;
Biological process	nucleus organization; cytoplasmic microtubule organization; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84942
	71968
	ENSG00000177082
	ENSMUSG00000025722
	Q6P4I2; Q5RKY8
	Q9CWR1
	NM_032856
	NM_028026
	NP_116245; NP_116245.2
	NP_082302
	Wikidata
View/Edit Human	View/Edit Mouse

The integrator complex assembly factor WDR73 is a protein that in humans is encoded by the gene WDR73. This protein participates in the assembly of the multi-protein complex called the integrator complex, which regulates RNA polymerase II.

Function

The protein WDR73 interacts with two subunits of the integrator complex, INTS9 and INTS11, and helps them bind together to form a heterodimer through stabilization. This blocks the active site of INTS11. BRAT1 then comes and takes WDR73's place at the active site, releasing it, and subsequently importing INTS9 and INTS11 into the cell nucleus.

Structure

Most of this protein consists of 6 WD40 repeat domains. This type of domain is common in scaffold proteins and often participates in protein-protein or protein-RNA interactions.

Medical significance

Pathogenic mutations in WDR73 is associated with a neurodegenerative disorder called type 1 Galloway-Mowat syndrome (GAMOS1). Symptoms can include microcephaly, various forms of brain atrophy, and movement disorders. It is inherited in an autosomal recessive manner.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177082 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025722 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 6 "Integrator complex assembly factor WDR73". uniprot.org. UniProt consortium. Retrieved 2026-11-01.
↑ Schapira M, Tyers M, Torrent M, Arrowsmith CH (November 2017). "WD40 repeat domain proteins: a novel target class?" (PDF). Nature reviews Drug discovery. 16 (11): 773–86. doi:10.1038/nrd.2017.179.
1 2 3 McKusick VA, Kniffin CL (2025-09-22). "GALLOWAY-MOWAT SYNDROME 1; GAMOS1". OMIM. Johns Hopkins university. Retrieved 2026-11-01.
↑ Sabath K, Jonas S (2022-12-01). "Take a break: Transcription regulation and RNA processing by the Integrator complex". Current Opinion in Structural Biology. 77: 102443. doi:10.1016/j.sbi.2022.102443.{{cite journal}}: CS1 maint: article number as page number (link)

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177082 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025722 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 3 4 5 6 "Integrator complex assembly factor WDR73". uniprot.org. UniProt consortium. Retrieved 2026-11-01.

[6] Schapira M, Tyers M, Torrent M, Arrowsmith CH (November 2017). "WD40 repeat domain proteins: a novel target class?" (PDF). Nature reviews Drug discovery. 16 (11): 773–86. doi:10.1038/nrd.2017.179.

[omim-7] 1 2 3 McKusick VA, Kniffin CL (2025-09-22). "GALLOWAY-MOWAT SYNDROME 1; GAMOS1". OMIM. Johns Hopkins university. Retrieved 2026-11-01.

[8] Sabath K, Jonas S (2022-12-01). "Take a break: Transcription regulation and RNA processing by the Integrator complex". Current Opinion in Structural Biology. 77: 102443. doi:10.1016/j.sbi.2022.102443.{{cite journal}}: CS1 maint: article number as page number (link)