WDTC1

WDTC1
Identifiers
Aliases	WDTC1, ADP, DCAF9, WD and tetratricopeptide repeats 1
External IDs	MGI: 2685541; GeneCards: WDTC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I7N
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,308,636 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,080,792 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; pancreatic ductal cell; ; cardia; ; apex of heart; ; granulocyte; ; left ventricle; ; right auricle of heart; ; left testis; ; right testis;
	Top expressed in
	muscle of thigh; ; neural layer of retina; ; spermatid; ; zygote; ; spermatocyte; ; granulocyte; ; ankle joint; ; seminiferous tubule; ; lip; ; extensor digitorum longus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme inhibitor activity; histone binding; histone deacetylase binding; protein binding;
Cellular component	cytosol; nucleus; nucleoplasm;
Biological process	regulation of cell size; negative regulation of catalytic activity; in utero embryonic development; negative regulation of transcription by RNA polymerase II; negative regulation of fatty acid biosynthetic process; protein ubiquitination; multicellular organism growth; glucose metabolic process; cellular response to insulin stimulus; cellular chemical homeostasis; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23038
	230796
	ENSG00000142784
	ENSMUSG00000037622
	Q8N5D0
	Q80ZK9
	NM_001276252; NM_015023
	NM_199306
	NP_001263181; NP_055838
	NP_955010
	Wikidata
View/Edit Human	View/Edit Mouse

WD and tetratricopeptide repeats protein 1, also called "adipose homolog", is a protein that in humans is encoded by the gene WDTC1. It is associated with obesity.

WDTC1 is a gene that codes for a protein acting as a suppressor in lipid accumulation. WDTC1 protein consists of seven WD40 domains, three transient receptor potential channel protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus. Reduced expression or disruption of WDTC1 gene is associated with obesity, increased triglyceride accumulation, and adipogenesis. WDTC1 is a factor in a complex composed of DDB1, CUL4, and ROC1 that restricts transcription in adipogenesis.

Model organisms

Studies of phenotype of mice showed that having a loss of an allele resulted in obesity and poor metabolic profiles. Transgenic expression of the WDTC1 gene in mice showed the opposite effect with mice having less adipose.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142784 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037622 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, et al. (September 2007). "Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195–207. doi:10.1016/j.cmet.2007.08.001. PMC 2587167. PMID 17767906.
↑ "ScienceDaily: 'Skinny Gene' Exists". Retrieved 2007-09-05.
↑ Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK, et al. (March 2009). "WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake". Obesity. 17 (3): 593–600. doi:10.1038/oby.2008.561. PMC 2874970. PMID 19238144.
↑ Ducos E, Vergès V, Dugé de Bernonville T, Blanc N, Giglioli-Guivarc'h N, Dutilleul C (September 2017). "Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants". Genetics. 207 (1): 153–162. doi:10.1534/genetics.116.198382. PMC 5586369. PMID 28663238.
↑ Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016). "The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase". EMBO Reports. 17 (5): 638–47. doi:10.15252/embr.201540500. PMC 5341520. PMID 27113764.
↑ Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016). "The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase". EMBO Reports. 17 (5): 638–47. doi:10.15252/embr.201540500. PMC 5341520. PMID 27113764.

External links

Born lucky: Scientists discover "skinny gene" - MSNBC

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142784 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17767906-5] Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, et al. (September 2007). "Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195–207. doi:10.1016/j.cmet.2007.08.001. PMC 2587167. PMID 17767906.

[6] "ScienceDaily: 'Skinny Gene' Exists". Retrieved 2007-09-05.

[pmid19238144-7] Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK, et al. (March 2009). "WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake". Obesity. 17 (3): 593–600. doi:10.1038/oby.2008.561. PMC 2874970. PMID 19238144.

[8] Ducos E, Vergès V, Dugé de Bernonville T, Blanc N, Giglioli-Guivarc'h N, Dutilleul C (September 2017). "Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants". Genetics. 207 (1): 153–162. doi:10.1534/genetics.116.198382. PMC 5586369. PMID 28663238.

[9] Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016). "The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase". EMBO Reports. 17 (5): 638–47. doi:10.15252/embr.201540500. PMC 5341520. PMID 27113764.

[10] Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016). "The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase". EMBO Reports. 17 (5): 638–47. doi:10.15252/embr.201540500. PMC 5341520. PMID 27113764.