WRNIP1

WRNIP1
Identifiers
Aliases	WRNIP1, WHIP, bA420G6.2, Werner helicase interacting protein 1, WRN helicase interacting protein 1, CFAP93, FAP93
External IDs	OMIM: 608196; MGI: 1926153; GeneCards: WRNIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VHS, 3VHT
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,786,952 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	33,006,592 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; skin of arm; ; internal globus pallidus; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; anterior pituitary; ; ventricular zone; ; cerebellar vermis; ; body of pancreas; ; myocardium of left ventricle;
	Top expressed in
	habenula; ; vestibular membrane of cochlear duct; ; ventromedial nucleus; ; supraoptic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; Paneth cell; ; dorsomedial hypothalamic nucleus; ; Gonadal ridge; ; endocardial cushion; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATPase activity; protein binding; hydrolase activity; ATP binding; metal ion binding; identical protein binding; enzyme activator activity; single-stranded DNA helicase activity;
Cellular component	perinuclear region of cytoplasm; membrane; nucleus; cytoplasm; replisome;
Biological process	DNA replication; DNA synthesis involved in DNA repair; regulation of DNA-dependent DNA replication initiation; DNA repair; cellular response to DNA damage stimulus; immune system process; DNA-dependent DNA replication; regulation of DNA repair; DNA recombination; DNA replication, Okazaki fragment processing; positive regulation of catalytic activity; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56897
	78903
	ENSG00000124535
	ENSMUSG00000021400
	Q96S55
	Q91XU0
	NM_020135; NM_130395
	NM_030215
	NP_064520; NP_569079
	NP_084491
	Wikidata
View/Edit Human	View/Edit Mouse

ATPase WRNIP1 is an enzyme that is encoded by the WRNIP1 gene in humans. The protein is a member of AAA ATPase family.

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.

Interactions

WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124535 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021400 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.
1 2 "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

External links

FactorBook WHIP

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124535 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021400 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11301316-5] 1 2 Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.

[entrez-6] 1 2 "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

WRNIP1

Interactions

References

Further reading

External links