The film was a moderate financial success, but critical reviews were overwhelmingly negative, regarding Wholly Moses! as an inferior imitation of Monty Python's The Life of Brian which featured a similar premise.
Plot
Harvey and Zoey, two tourists travelling through Israel, discover an ancient scroll describing the life of Herschel, the man who was almost Moses. Herschel thinks he hears God commanding him to go to Egypt, but actually, he has overheard God giving His instructions to Moses at the burning bush. He tries to obey this command, but Moses always seems to be one step ahead of him. Several other biblical stories, such as Lot and his wife, David and Goliath, and the miracles of Jesus, are also parodied in this story of the life of a man trying to follow the path to God, but somehow always seeming to lose his way.
Because of a production hiatus imposed on their television show by WTTW, Roger Ebert and Gene Siskel did not review the film on Sneak Previews. However, Ebert's print review in The Chicago Sun-Times was scathing. He wrote how comedy which could be successful successful in the short skits Weis might have directed on Saturday Night Live were less effective in a feature length film: "The movie's not funny on its own, and since movie audiences are scarcely going to be shocked by its mild but relentlessly repetitive irreverence, it all boils down to a very old joke [of] dressing people up in Biblical costume and having them speak in contemporary terms."
In another print review, for The Chicago Tribune, Siskel wrote how Wholly Moses! proves the truth of an addage: "Never go to a film with an exclamation point in its title" (The Beatles' "Help!" being a possible exception)", and noted it was similar in concept to Monty Python's Life of Brian but far less successful or humorous.
When the film was released on DVD, John Sinnott of DVD Talk echoed Siskel's commentary about how Wholly Moses! was clearly intended to capitalize on the success Life of Bryan. "But they got it all wrong. The jokes are bad, the setups lame and the laughs nonexistent. The script is so bad that I can't imagine how the project ever got green lighted."
