ZBTB14

ZBTB14
Identifiers
Aliases	ZBTB14, ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478, zinc finger and BTB domain containing 14
External IDs	OMIM: 602126; MGI: 1195345; GeneCards: ZBTB14
Gene location (Human)
Chr.	Chromosome 18 (human)
End	5,297,053 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	69,698,194 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; lymph node; ; monocyte; ; granulocyte; ; ganglionic eminence; ; gallbladder; ; ventricular zone; ; C1 segment; ; gonad; ; rectum;
	Top expressed in
	ureter; ; condyle; ; Paneth cell; ; ciliary body; ; fossa; ; medullary collecting duct; ; lacrimal gland; ; ascending aorta; ; cumulus cell; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; protein binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; nucleolus; cytosol; aggresome;
Biological process	cardiac septum development; heart valve development; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; coronary vasculature development; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7541
	22666
	ENSG00000198081
	ENSMUSG00000049672
	O43829
	Q08376
	NM_003409; NM_001143823; NM_001243702; NM_001243704
	NM_009547; NM_001356282; NM_001356283
	NP_001137295; NP_001230631; NP_001230633; NP_003400
	NP_033573; NP_001343211; NP_001343212
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain-containing protein 14 is a protein that in humans is encoded by the ZBTB14 gene (previously ZFP161). The ZBTB14 protein acts as a transcription activator for the dopamine transporter, while instead acting as a transcription repressor for FMR1, MYC, and thymidine kinases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198081 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049672 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sobek-Klocke I, Disque-Kochem C, Ronsiek M, Klocke R, Jockusch H, Breuning A, Ponstingl H, Rojas K, Overhauser J, Eichenlaub-Ritter U (Sep 1997). "The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)". Genomics. 43 (2): 156–64. doi:10.1006/geno.1997.4784. PMID 9244432.
↑ "Entrez Gene: ZFP161 zinc finger protein 161 homolog (mouse)".
↑ "O43829 · ZBT14_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-25.

Numoto M, Niwa O, Kaplan J, et al. (1993). "Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins". Nucleic Acids Res. 21 (16): 3767–75. doi:10.1093/nar/21.16.3767. PMC 309887. PMID 8367294.
Sugiura K, Muro Y, Nagai Y, et al. (1997). "Expression cloning and intracellular localization of a human ZF5 homologue". Biochim. Biophys. Acta. 1352 (1): 23–6. doi:10.1016/s0167-4781(97)00045-6. PMID 9177479.
Obata T, Yanagidani A, Yokoro K, et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc.1998.9970. PMID 10049742.
Numoto M, Yokoro K, Koshi J (1999). "ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association". Biochem. Biophys. Res. Commun. 256 (3): 573–8. doi:10.1006/bbrc.1999.0375. PMID 10080939.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee KH, Kwak YD, Kim DH, et al. (2004). "Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter". Biochem. Biophys. Res. Commun. 313 (4): 969–76. doi:10.1016/j.bbrc.2003.11.183. PMID 14706637.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang J, Kudoh J, Takayanagi A, Shimizu N (2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochem. Biophys. Res. Commun. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
Orlov SV, Kuteĭkin-Tepliakov KB, Grishin AV, et al. (2006). "[Transcription factor ZF5 regulates expression of mammalian gene containing GCC-triplet repeats in 5'-regulatory region in human hepatoma HepG2 cells]". Tsitologiia. 48 (3): 246–52. PMID 16805315.
Orlov SV, Kuteykin-Teplyakov KB, Ignatovich IA, et al. (2007). "Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5". FEBS J. 274 (18): 4848–62. doi:10.1111/j.1742-4658.2007.06006.x. PMID 17714511. S2CID 31019370.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198081 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049672 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9244432-5] Sobek-Klocke I, Disque-Kochem C, Ronsiek M, Klocke R, Jockusch H, Breuning A, Ponstingl H, Rojas K, Overhauser J, Eichenlaub-Ritter U (Sep 1997). "The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)". Genomics. 43 (2): 156–64. doi:10.1006/geno.1997.4784. PMID 9244432.

[entrez-6] "Entrez Gene: ZFP161 zinc finger protein 161 homolog (mouse)".

[uniprot-7] "O43829 · ZBT14_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-25.

ZBTB14

See also

References

Further reading