ZDHHC17

ZDHHC17

Identifiers

ZDHHC17, HIP14, HIP3, HYPH, HSPC294, zinc finger DHHC-type containing 17, DHHC-17, zinc finger DHHC-type palmitoyltransferase 17, DHHC17

External IDs

OMIM: 607799; MGI: 2445110; GeneCards: ZDHHC17

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3EU9

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.1.225	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	12q21.2	Start	76,764,103 bp
Band	12q21.2	End	76,853,696 bp

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	10\|10 D1	Start	110,777,641 bp
Band	10\|10 D1	End	110,846,001 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

corpus callosum

cerebellar vermis

Brodmann area 23

lateral nuclear group of thalamus

external globus pallidus

pars compacta

superior vestibular nucleus

pars reticulata

subthalamic nucleus

pons

Top expressed in

neural layer of retina

gastrula

Rostral migratory stream

lobe of cerebellum

cerebellar vermis

ascending aorta

nucleus of stria terminalis

otolith organ

inferior colliculi

utricle

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein-cysteine S-palmitoyltransferase activity transferase activity magnesium ion transmembrane transporter activity signal transducer activity palmitoyltransferase activity protein binding identical protein binding acyltransferase activity
Cellular component	integral component of membrane Golgi apparatus intracellular membrane-bounded organelle membrane Golgi membrane Golgi-associated vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle presynaptic membrane plasma membrane synapse cell junction cytosol
Biological process	protein palmitoylation positive regulation of I-kappaB kinase/NF-kappaB signaling lipoprotein transport signal transduction magnesium ion transmembrane transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23390


320150


ENSG00000186908


ENSMUSG00000035798


Q8IUH5


Q80TN5

RefSeq (mRNA)


NM_015336 NM_001359626


NM_172554 NM_001359622 NM_001359624

RefSeq (protein)


NP_056151 NP_001346555


NP_766142 NP_001346551 NP_001346553

Location (UCSC)

Chr 12: 76.76 – 76.85 Mb

Chr 10: 110.78 – 110.85 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Palmitoyltransferase ZDHHC17 is an enzyme that contains a DHHC domain that in humans is encoded by the ZDHHC17 gene.

Interactions

ZDHHC17 has been shown to interact with Huntingtin.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186908 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035798 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Goytain A, Hines RM, Quamme GA (Nov 2008). "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport". The Journal of Biological Chemistry. 283 (48): 33365–74. doi:10.1074/jbc.M801469200. PMC 2662264. PMID 18794299.
↑ "Entrez Gene: ZDHHC17 zinc finger, DHHC-type containing 17".
↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.

Further reading

Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD (Dec 2004). "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase". Oncogene. 23 (57): 9230–7. doi:10.1038/sj.onc.1208171. PMC 2908390. PMID 15489887.
Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A (Dec 2004). "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins". Neuron. 44 (6): 977–86. doi:10.1016/j.neuron.2004.11.027. PMID 15603740. S2CID 14406733.

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