Rabenosyn-5

RBSN

Identifiers

RBSN, Rabenosyn-5, ZFYVE20, rabenosyn, RAB effector

External IDs

OMIM: 609511; MGI: 1925537; GeneCards: RBSN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YZM, 1Z0J, 1Z0K

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p25.1	Start	15,070,073 bp
Band	3p25.1	End	15,099,163 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 D1	Start	92,163,693 bp
Band	6\|6 D1	End	92,191,906 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

endothelial cell

myocardium of left ventricle

cardiac muscle tissue of right atrium

skin of arm

tibialis anterior muscle

cerebellar vermis

Brodmann area 23

Brodmann area 46

middle temporal gyrus

internal globus pallidus

Top expressed in

otic vesicle

Rostral migratory stream

supraoptic nucleus

hand

otolith organ

utricle

lumbar subsegment of spinal cord

medullary collecting duct

nucleus of stria terminalis

ascending aorta

More reference expression data


More reference expression data

Gene ontology
Molecular function	zinc ion binding metal ion binding protein binding nucleic acid binding
Cellular component	endosome early endosome membrane intracellular membrane-bounded organelle membrane cytoplasmic side of endosome membrane plasma membrane endosome membrane extracellular exosome cytosol
Biological process	endosomal vesicle fusion endocytosis vacuole inheritance Golgi to endosome transport blood coagulation endosomal transport protein transport regulation of Golgi organization Golgi to lysosome transport early endosome to Golgi transport transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


64145


78287


ENSG00000131381


ENSMUSG00000014550


Q9H1K0


Q80Y56

RefSeq (mRNA)


NM_001302378 NM_022340


NM_030081

RefSeq (protein)


NP_001289307 NP_071735


NP_084357

Location (UCSC)

Chr 3: 15.07 – 15.1 Mb

Chr 6: 92.16 – 92.19 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Rabenosyn-5 is a protein that in humans is encoded by the RBSN gene (previously ZFYVE20). Rabenosyn-5 is important for the fusion and recycling of endosomes. As part of this, it acts as an effector for RAB4A/RAB5A.

Interactions

Rabenosyn-5 has been shown to interact with RAB5A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131381 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014550 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Nov 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588. PMID 11062261.
↑ "Entrez Gene: ZFYVE20 zinc finger, FYVE domain containing 20".
1 2 "Q9H1K0 · RBNS5_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-25.

Further reading

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Eathiraj S, Pan X, Ritacco C, Lambright DG (2005). "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5". Nature. 436 (7049): 415–9. Bibcode:2005Natur.436..415E. doi:10.1038/nature03798. PMC 1360218. PMID 16034420.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane". Mol. Biol. Cell. 15 (5): 2410–22. doi:10.1091/mbc.E03-10-0733. PMC 404033. PMID 15020713.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822. S2CID 6596498.

v t e PDB gallery
1yzm: Structure of Rabenosyn (458-503), Rab4 binding domain 1z0j: Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5 1z0k: Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5

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