ZMYND11

ZMYND11
Identifiers
Aliases	ZMYND11, BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDs	OMIM: 608668; MGI: 1913755; GeneCards: ZMYND11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NS5, 5HDA
Gene location (Human)
Chr.	Chromosome 10 (human)
End	254,637 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	9,815,366 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; caput epididymis; ; tail of epididymis; ; corpus epididymis; ; lactiferous duct; ; inferior ganglion of vagus nerve; ; corpus callosum; ; superior vestibular nucleus; ; postcentral gyrus; ; Brodmann area 46;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; iris; ; barrel cortex; ; conjunctival fornix; ; ureter; ; Region I of hippocampus proper; ; substantia nigra; ; Epithelium of choroid plexus; ; medullary collecting duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; transcription coregulator activity; metal ion binding; protein binding; transcription corepressor activity; histone binding; double-stranded DNA binding; zinc ion binding; methylated histone binding;
Cellular component	nucleoplasm; chromosome; nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; transcription, DNA-templated; negative regulation of JNK cascade; cell cycle; cell population proliferation; viral process; regulation of transcription elongation from RNA polymerase II promoter; defense response to virus; negative regulation of nucleic acid-templated transcription; chromatin organization; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10771
	66505
	ENSG00000015171
	ENSMUSG00000021156
	Q15326
	Q8R5C8
NM_001202464; NM_001202465; NM_001202466; NM_001202467; NM_001202468;
	NM_006624; NM_212479; NM_001330057
NM_001199141; NM_144516; NM_001347470; NM_001347471; NM_001347472;
	NM_001347473; NM_001347474; NM_001347476; NM_001347477; NM_001347479; NM_001347480; NM_001347481
NP_001189393; NP_001189394; NP_001189395; NP_001189396; NP_001189397;
	NP_001316986; NP_006615; NP_997644; NP_001357026; NP_001357027; NP_001357028; NP_001357029; NP_001357030; NP_001357031; NP_001357032; NP_001357033; NP_001357034; NP_001357035; NP_001357036; NP_001357037; NP_001357038; NP_001357039; NP_001357040; NP_001357041; NP_001357042; NP_001357043; NP_001357044; NP_001357045; NP_001357046; NP_001357047; NP_001357048; NP_001357049; NP_001357050; NP_001357051; NP_001357052; NP_001357053
NP_001186070; NP_001334399; NP_001334400; NP_001334401; NP_001334402;
	NP_001334403; NP_001334405; NP_001334406; NP_001334408; NP_001334409; NP_001334410; NP_653099
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

ZMYND11 has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000015171 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021156 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, et al. (July 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–3169. doi:10.1002/j.1460-2075.1995.tb07318.x. PMC 394377. PMID 7621829.
↑ Masselink H, Bernards R (March 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–1546. doi:10.1038/sj.onc.1203421. PMID 10734313.
1 2 "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".
1 2 Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (April 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–264. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.
↑ Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, et al. (November 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–535. doi:10.1016/s0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.
↑ Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–2178. PMID 12894593.
↑ Wen H, Li Y, Xi Y, Jiang S, Stratton S, Peng D, et al. (April 2014). "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression". Nature. 508 (7495): 263–268. doi:10.1038/nature13045. PMC 4142212. PMID 24590075.

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (April 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–14066. doi:10.1074/jbc.M010320200. PMID 11148209.
Ansieau S, Leutz A (February 2002). "The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif". The Journal of Biological Chemistry. 277 (7): 4906–4910. doi:10.1074/jbc.M110078200. PMID 11733528.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Isobe T, Uchida C, Hattori T, Kitagawa K, Oda T, Kitagawa M (January 2006). "Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69". Biochemical and Biophysical Research Communications. 339 (1): 367–374. doi:10.1016/j.bbrc.2005.11.028. hdl:10271/294. PMID 16300738.
Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, et al. (January 2006). "BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway". Molecular and Cellular Biology. 26 (2): 448–456. doi:10.1128/MCB.26.2.448-456.2006. PMC 1346911. PMID 16382137.
Velasco G, Grkovic S, Ansieau S (June 2006). "New insights into BS69 functions". The Journal of Biological Chemistry. 281 (24): 16546–16550. doi:10.1074/jbc.M600573200. PMID 16565076.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000015171 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021156 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hateboer_1995-5] Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, et al. (July 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–3169. doi:10.1002/j.1460-2075.1995.tb07318.x. PMC 394377. PMID 7621829.

[Masselink_2000-6] Masselink H, Bernards R (March 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–1546. doi:10.1038/sj.onc.1203421. PMID 10734313.

[entrez-7] 1 2 "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".

[Kurozumi_1998-8] 1 2 Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (April 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–264. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.

[Hughes-Davies_2003-9] Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, et al. (November 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–535. doi:10.1016/s0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.

[Wei_2003-10] Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–2178. PMID 12894593.

[11] Wen H, Li Y, Xi Y, Jiang S, Stratton S, Peng D, et al. (April 2014). "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression". Nature. 508 (7495): 263–268. doi:10.1038/nature13045. PMC 4142212. PMID 24590075.

ZMYND11

Function

Interactions

References

Further reading