ZNF277

ZNF277
Identifiers
Aliases	ZNF277, NRIF4, ZNF277P, zinc finger protein 277
External IDs	OMIM: 605465; MGI: 1890393; GeneCards: ZNF277
Gene location (Human)
Chr.	Chromosome 7 (human)
End	112,343,934 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	40,495,901 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; germinal epithelium; ; islet of Langerhans; ; body of pancreas; ; ganglionic eminence; ; jejunal mucosa; ; oocyte; ; skin of thigh; ; gallbladder;
	Top expressed in
	primary oocyte; ; cumulus cell; ; efferent ductule; ; vas deferens; ; abdominal wall; ; medial ganglionic eminence; ; zygote; ; secondary oocyte; ; ovary; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of cellular senescence; regulation of transcription, DNA-templated; transcription, DNA-templated; cellular response to hydrogen peroxide; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11179
	246196
	ENSG00000198839
	ENSMUSG00000055917
	Q9NRM2
	E9Q6D6
	NM_021994
	NM_172575; NM_178845
	NP_068834
	NP_766163; NP_849173
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 277 is a protein that in humans is encoded by the ZNF277 gene (previously ZNF277P). ZNF277 is predicted to be a transcription factor which is involved in regulating cellular senescence. The gene ZNF277 was truncated from its ancestral form, leading to it be labeled as a pseudogene in some places, but is now thought to produce a functionally modified protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198839 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055917 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liang H, Guo W, Nagarajan L (Aug 2000). "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277". Genomics. 66 (2): 226–8. doi:10.1006/geno.2000.6198. PMID 10860669.
↑ Liang H, Castro PD, Ma J, Nagarajan L (Oct 2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genet Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005.03.019. PMID 16213364.
1 2 Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.
1 2 "Entrez Gene: ZNF277P zinc finger protein 277 pseudogene".
↑ "Q9NRM2 · ZN277_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

Kumar S; Connor JR; Dodds RA; et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Lim J; Hao T; Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Ewing RM; Chu P; Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198839 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055917 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10860669-5] Liang H, Guo W, Nagarajan L (Aug 2000). "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277". Genomics. 66 (2): 226–8. doi:10.1006/geno.2000.6198. PMID 10860669.

[pmid16213364-6] Liang H, Castro PD, Ma J, Nagarajan L (Oct 2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genet Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005.03.019. PMID 16213364.

[pmid16395595-7] 1 2 Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.

[entrez-8] 1 2 "Entrez Gene: ZNF277P zinc finger protein 277 pseudogene".

[9] "Q9NRM2 · ZN277_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

ZNF277

References

Further reading