Zinc finger and scan domain containing 4

ZSCAN4
Identifiers
Aliases	ZSCAN4, ZNF494, zinc finger and SCAN domain containing 4
External IDs	OMIM: 613419; MGI: 3708485; GeneCards: ZSCAN4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	57,679,152 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	11,136,245 bp
RNA expression pattern
	Top expressed in
	placenta; ; apex of heart; ; olfactory zone of nasal mucosa; ; right uterine tube; ; skin of abdomen; ; urinary bladder; ; skin of leg; ; minor salivary glands; ; skin of hip; ; body of stomach;
	Top expressed in
	zygote; ; secondary oocyte; ; epiblast; ; spleen; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	telomere; chromosome; nucleus;
Biological process	telomere maintenance via telomere lengthening; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of mitotic recombination; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	201516
	665902
	ENSG00000180532
	ENSMUSG00000070828
	Q8NAM6
	Q3URS2
	NM_152677; NM_001384833
	NM_001110316
	NP_689890
	NP_001103786
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and SCAN domain containing 4 is a protein that in humans is encoded by the ZSCAN4 gene.

Function

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture.

1 2 3 GRCh38: Ensembl release 89: ENSG00000180532 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070828 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger and SCAN domain containing 4". Retrieved 2017-06-05.
↑ Zalzman M, Falco G, Sharova LV, Nishiyama A, Thomas M, Lee SL, et al. (April 2010). "Zscan4 regulates telomere elongation and genomic stability in ES cells". Nature. 464 (7290): 858–863. Bibcode:2010Natur.464..858Z. doi:10.1038/nature08882. PMC 2851843. PMID 20336070.

Lee K, Gollahon LS (2014). "Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status". Cancer Biology & Therapy. 15 (8): 1094–1105. doi:10.4161/cbt.29220. PMC 4119077. PMID 24840609.
Lee K, Gollahon LS (2015). "ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity". Biochemical and Biophysical Research Communications. 466 (4): 644–649. Bibcode:2015BBRC..466..644L. doi:10.1016/j.bbrc.2015.09.107. PMID 26403970.
Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, et al. (2017). "Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos". In Vitro Cellular & Developmental Biology. Animal. 53 (2): 179–190. doi:10.1007/s11626-016-0097-y. PMC 5311086. PMID 27699651.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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