ZSWIM7

ZSWIM7
Identifiers
Aliases	ZSWIM7, SWS1, zinc finger SWIM-type containing 7
External IDs	OMIM: 614535; MGI: 1916997; GeneCards: ZSWIM7
Gene location (Human)
Chr.	Chromosome 17 (human)
End	15,999,717 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,172,201 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; right adrenal cortex; ; left adrenal gland; ; C1 segment; ; muscle of thigh; ; left adrenal cortex; ; gastrocnemius muscle; ; monocyte; ; oocyte; ; prefrontal cortex;
	Top expressed in
	muscle of thigh; ; spermatocyte; ; right kidney; ; seminiferous tubule; ; plantaris muscle; ; spermatid; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; extensor digitorum longus muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding;
Cellular component	Shu complex; nucleus;
Biological process	protein stabilization; DNA recombination; double-strand break repair via homologous recombination; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	125150
	69747
	ENSG00000214941
	ENSMUSG00000014243
	Q19AV6
	Q9CWQ2
	NM_001042698; NM_001042697
	NM_027198
	NP_001036162; NP_001036163
	NP_081474
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger SWIM domain-containing protein 7 is a protein that in humans is encoded by the ZSWIM7 gene. This protein interacts with SWSAP1 and SPIDR to form a complex called the Shu complex which is involved in DNA repair. In particular, it participates in DNA double-strand break repair, and is particularly important during meiosis.

Medical Significance

Pathogenic mutations in ZSWIM7 have been associated with infertility. For example, it can cause a type of nonobstructive azoospermia designated spermatogenic failure-71 (SPGF71), following an apparent autosomally recessive pattern of inheritance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000214941 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014243 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Zinc finger SWIM domain-containing protein 7". uniprot.org. UniProt consortium. Retrieved 2026-10-15.
↑ Ozturk S (2023-05-03). "Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia". Cell Cycle. 22 (9): 1021–61. doi:10.1080/15384101.2023.2171544.
↑ O'Neill MJ (2022-04-08). "SPERMATOGENIC FAILURE 71; SPGF71". OMIM. Johns Hopkins university. Retrieved 2026-10-15.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000214941 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014243 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 3 "Zinc finger SWIM domain-containing protein 7". uniprot.org. UniProt consortium. Retrieved 2026-10-15.

[6] Ozturk S (2023-05-03). "Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia". Cell Cycle. 22 (9): 1021–61. doi:10.1080/15384101.2023.2171544.

[7] O'Neill MJ (2022-04-08). "SPERMATOGENIC FAILURE 71; SPGF71". OMIM. Johns Hopkins university. Retrieved 2026-10-15.