Zedoresertib

Zedoresertib
Clinical data
Other namesDebio 0123
Identifiers
  • 6-(2,6-dichlorophenyl)-8-methyl-2-[3-methyl-4-(1-methylpiperidin-4-yl)anilino]-7H-pyrimido[4,5-d]pyrimidin-5-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC26H28Cl2N6O
Molar mass511.45 g·mol−1
3D model (JSmol)
  • CC1=C(C=CC(=C1)NC2=NC=C3C(=N2)N(CN(C3=O)C4=C(C=CC=C4Cl)Cl)C)C5CCN(CC5)C
  • InChI=InChI=1S/C26H28Cl2N6O/c1-16-13-18(7-8-19(16)17-9-11-32(2)12-10-17)30-26-29-14-20-24(31-26)33(3)15-34(25(20)35)23-21(27)5-4-6-22(23)28/h4-8,13-14,17H,9-12,15H2,1-3H3,(H,29,30,31)
  • Key:VWHNEYAANMETIA-UHFFFAOYSA-N

Zedoresertib is an investigational new drug that is being evaluated for the treatment of solid tumors. It is a WEE1 kinase inhibitor.

References

  1. ↑ "Debio 0123". AdisInsight. Springer Nature Switzerland AG.
  2. ↑ Zhang Z, Harish R, Elahi N, Saini S, Telia A, Kundlas M, et al. (June 2025). "Targeting WEE1 Kinase for Breast Cancer Therapeutics: An Update". International Journal of Molecular Sciences. 26 (12): 5701. doi:10.3390/ijms26125701. PMC 12192920. PMID 40565165.