Cetirizine/pseudoephedrine

Cetirizine/pseudoephedrine
Combination of
CetirizineAntihistamine
PseudoephedrineDecongestant
Clinical data
Trade namesZyrtec-D, others
AHFS/Drugs.comMultum Consumer Information
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status

Cetirizine/pseudoephedrine, sold under the brand name Zyrtec-D among others, is an antihistamine and decongestant formulation used for the symptoms related to seasonal allergic rhinitis. It is a fixed-dose combination medication that contains cetirizine, a second-generation antihistamine, as the hydrochloride; and pseudoephedrine, a sympathomimetic nasal decongestant, as the hydrochloride. It is taken by mouth.

Cetirizine/pseudoephedrine was approved by the US Food and Drug Administration in 2001, as a prescription medication and as an over-the-counter medication (OTC) in 2007.

References

  1. ↑ "Zyrtec-D- cetirizine hydrochloride and pseudoephedrine hydrochloride tablet, film coated, extended release". DailyMed. 20 March 2025. Retrieved 26 May 2025.
  2. 1 2 3 4 "Zyrtec-D Allergy Plus Congestion- cetirizine hydrochloride and pseudoephedrine hydrochloride tablet, film coated, extended release". DailyMed. 25 April 2022. Retrieved 28 September 2022.
  3. ↑ Badorrek P, Dick M, Schauerte A, Hecker H, Murdoch R, Luettig B, et al. (February 2009). "A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis". International Journal of Clinical Pharmacology and Therapeutics. 47 (2). Dustri-Verlgag Dr. Karl Feistle: 71–77. doi:10.5414/cpp47071. PMID 19203562.{{cite journal}}: CS1 maint: overridden setting (link)
  4. ↑ Grosclaude M, Mees K, Pinelli ME, Lucas M, Van de Venne H (June 1997). "Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis". Rhinology. 35 (2): 67–73. PMID 9299654.
  5. ↑ "Drug Approval Package: ZyrZyrtec-D 12 hr. Extended-Release Tablets (Cetirizine Hydrochloride & Pseudoephedrine Hydrochloride) NDA #21-150". U.S. Food and Drug Administration (FDA). 20 November 2001. Archived from the original on 1 April 2021. Retrieved 26 May 2025.
  6. ↑ "FDA approves J&J's non-prescription Zyrtec-D". PharmaTimes. 12 November 2007. Retrieved 12 December 2022.