CRIPT

CRIPT
Identificadores
Alias	CRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain
IDs externos	OMIM: 604594 MGI: 1929655 HomoloGene: 8572 GeneCards: CRIPT
Enfermedades genéticamente relacionadas
	short stature with microcephaly and distinctive facies
Ontología génica
Función molecular	• microtubule binding; • scaffold protein binding; • PDZ domain binding; • GO:0001948, GO:0016582 unión a proteína plasmática; • GO:0032403 protein-containing complex binding;
Componente celular	• citoplasma; • dendritic shaft; • unión celular; • soma; • Espina dendrítica; • dendrita; • cell projection; • sinapsis; • nucléolo; • GO:0097483, GO:0097481 postsynaptic density; • núcleo celular; • fibrillar center;
Proceso biológico	• regulation of postsynaptic density protein 95 clustering; • protein localization to microtubule; • cytoplasmic microtubule organization; • establishment of protein localization;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	Más referencias a datos de expressión
Ortólogos
	9419
	56724
	ENSG00000119878
	ENSMUSG00000024146
	Q9P021
	O70333
	NM_014171
	NM_019936
	NP_054890
	NP_064320
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La proteína de unión a PDZ rica en cisteína es una proteína pequeña y altamente conservada de 101 aminoácidos. Se encuentra en mamíferos y plantas y se une selectivamente al tercer dominio PDZ (PDZ3) de PSD-95 a través de su extremo C. En humanos está codificada por el gen CRIPT.

Se ha demostrado que CRIPT interactúa con DLG3.

Referencias

↑ «Diseases that are genetically associated with CRIPT view/edit references on wikidata».
↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). «CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90». Neuron 20 (4): 693-707. PMID 9581762. doi:10.1016/S0896-6273(00)81009-0.
↑ «Entrez Gene: CRIPT cysteine-rich PDZ-binding protein».
↑ Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). «The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins». J Biochem 138 (2): 177-82. PMID 16091592. doi:10.1093/jb/mvi107.
↑ Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). «The PDZ1 domain of SAP90. Characterization of structure and binding». J Biol Chem 277 (9): 6967-73. PMID 11744724. doi:10.1074/jbc.M109453200.
↑ Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). «Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95». Nat Neurosci 2 (12): 1063-9. PMID 10570482. doi:10.1038/15990.
↑ Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). «Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102». J. Biol. Chem. (United States) 277 (24): 21697-711. ISSN 0021-9258. PMID 11937501. doi:10.1074/jbc.M112339200.

Datos: Q18034077

[1] «Diseases that are genetically associated with CRIPT view/edit references on wikidata».

[2] «Human PubMed Reference:».

[3] «Mouse PubMed Reference:».

[pmid9581762-4] Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). «CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90». Neuron 20 (4): 693-707. PMID 9581762. doi:10.1016/S0896-6273(00)81009-0.

[entrez-5] «Entrez Gene: CRIPT cysteine-rich PDZ-binding protein».

[pmid16091592-6] Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). «The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins». J Biochem 138 (2): 177-82. PMID 16091592. doi:10.1093/jb/mvi107.

[pmid11744724-7] Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). «The PDZ1 domain of SAP90. Characterization of structure and binding». J Biol Chem 277 (9): 6967-73. PMID 11744724. doi:10.1074/jbc.M109453200.

[pmid10570482-8] Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). «Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95». Nat Neurosci 2 (12): 1063-9. PMID 10570482. doi:10.1038/15990.

[pmid11937501-9] Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). «Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102». J. Biol. Chem. (United States) 277 (24): 21697-711. ISSN 0021-9258. PMID 11937501. doi:10.1074/jbc.M112339200.