RALGDS

RALGDS
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	1RAX, 2B3A, 2RGF, 3KH0
Identificadores
Alias	RALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator
IDs externos	OMIM: 601619 MGI: 107485 HomoloGene: 4562 GeneCards: RALGDS
Ontología génica
Función molecular	• GO:0001948, GO:0016582 unión a proteína plasmática; • guanyl-nucleotide exchange factor activity; • GO:0005083 GTPase regulator activity;
Componente celular	• citosol; • borde en cepillo; • citoplasma; • núcleo celular;
Proceso biológico	• small GTPase mediated signal transduction; • Ras protein signal transduction; • GO:0072468 transducción de señal; • GO:0048552 regulation of catalytic activity;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	; ;
	Más referencias a datos de expressión
Ortólogos
	5900
	19730
	ENSG00000160271
	ENSMUSG00000026821
	Q12967
	Q03385
	NM_006266; NM_001042368; NM_001271774; NM_001271775; NM_001271776
	NM_001145834; NM_001145835; NM_001145836; NM_009058
	NP_001035827; NP_001258703; NP_001258704; NP_001258705; NP_006257
	NP_001139306; NP_001139307; NP_001139308; NP_033084
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

Estimulador de disociación de nucleótidos de guanina ral (RALGDS) es una proteína que en los humanos está codificado por el gen RALGDS.

Interacciones

RALGDS ha sido mostrado para interaccionar con:

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
1 2 «Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator». Proc Natl Acad Sci U S A 91 (23): 11089-93. December 1994. PMC 45172. PMID 7972015. doi:10.1073/pnas.91.23.11089.
↑ «Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator».
1 2 Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). «Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization». Nat. Cell Biol. 4 (8): 547-55. PMID 12105416.
1 2 3 4 Spaargaren M, Bischoff JR (Diciembre de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. PMC 45488. PMID 7809086.
1 2 Boettner B, Govek EE, Cross J, Van Aelst L (Agosto de 2000). «The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin». Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064-9. PMC 16822. PMID 10922060.
1 2 Li W, Han M, Guan KL (Abril de 2000). «The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf». Genes Dev. 14 (8): 895-900. PMC 316541. PMID 10783161.
↑ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (Mayo de 2004). «Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization». J. Biol. Chem. 279 (21): 22353-61. PMID 15031288.
↑ Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (Febrero de 1997). «RalGDS functions in Ras- and cAMP-mediated growth stimulation». J. Biol. Chem. 272 (9): 5600-5. PMID 9038168.
↑ Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (Mayo de 1997). «Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras». Cell 89 (3): 457-67. PMID 9150145.
↑ Stang S, Bottorff D, Stone JC (Junio de 1997). «Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells». Mol. Cell. Biol. 17 (6): 3047-55. PMC 232157. PMID 9154803.
↑ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (Noviembre de 1997). «Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution». Oncogene 15 (22): 2675-85. PMID 9400994.
↑ Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (Octubre de 1999). «M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line». Blood 94 (7): 2433-44. PMID 10498616.
1 2 Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Marzo de 1999). «Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2». J. Biol. Chem. 274 (13): 8737-45. PMID 10085114.