RRAS
La proteína R-Ras asociada a Ras (RRAS ) es una proteína codificada en humanos por el gen RRAS .
Interacciones
La proteína RRAS ha demostrado ser capaz de interaccionar con:
Significación clínica
Existen 537 enfermedades descritas que coinciden con RRAS (p.e.:síndrome de Noonan )
Referencias
↑ Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (Feb de 1987). «Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes» . Cell 48 (1): 137-46. PMID 3098437 .
↑ «Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog» .
↑ Ortiz-Vega, Sara; Khokhlatchev Andrei, Nedwidek Maria, Zhang Xian-feng, Dammann Reinhard, Pfeifer Gerd P, Avruch Joseph (Feb. de 2002). «The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1». Oncogene (England) 21 (9): 1381-90. ISSN 0950-9232 . PMID 11857081 . doi :10.1038/sj.onc.1205192 .
↑ Wang, B; Zou J X, Ek-Rylander B, Ruoslahti E (Feb. de 2000). «R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras» . J. Biol. Chem. (UNITED STATES) 275 (7): 5222-7. ISSN 0021-9258 . PMID 10671570 .
↑ Fernandez-Sarabia, M J; Bischoff J R (Nov. de 1993). «Bcl-2 associates with the ras-related protein R-ras p23» . Nature (ENGLAND) 366 (6452): 274-5. ISSN 0028-0836 . PMID 8232588 . doi :10.1038/366274a0 .
↑ Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543 . PMID 12620389 .
↑ Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (Jul. de 2000). «Isoform-specific localization of A-RAF in mitochondria» . Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870-8. ISSN 0270-7306 . PMID 10848612 .
↑ Spaargaren, M; Bischoff J R (Dec. de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap» . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (26): 12609-13. ISSN 0027-8424 . PMID 7809086 .
↑ «MalaCards» . Consultado el 20 de enero de 2026 .
↑ «DISEASES - RRAS2» . diseases.jensenlab.org . Consultado el 20 de enero de 2026 .