RBBP4

RBBP4
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	2XU7, 3GFC, 4PBY, 4PBZ, 4PC0, 4R7A, 5FXY
Identificadores
Alias	RBBP4, NURF55, RBAP48, lin-53, retinoblastoma binding protein 4, RB binding protein 4, chromatin remodeling factor
IDs externos	OMIM: 602923 MGI: 1194912 HomoloGene: 21153 GeneCards: RBBP4
Ontología génica
Función molecular	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • ATP-dependent activity, acting on DNA; • GO:0031493 histone binding; • histone deacetylase binding; • GO:0001948, GO:0016582 unión a proteína plasmática; • nucleosomal DNA binding; • histone deacetylase activity;
Componente celular	• NuRD complex; • ESC/E(Z) complex; • CAF-1 complex; • Sin3 complex; • Nucleoplasma; • NURF complex; • núcleo celular; • citosol; • GO:0009327 complejo macromolecular;
Proceso biológico	• Remodelación de la cromatina; • GO:0009373 regulation of transcription, DNA-templated; • GO:0061641 CENP-A containing chromatin assembly; • transcription, DNA-templated; • regulación del ciclo celular; • GO:0034723 DNA replication-dependent chromatin assembly; • replicación de ADN; • negative regulation of gene expression, epigenetic; • ciclo celular; • negative regulation of cell population proliferation; • regulation of signal transduction by p53 class mediator; • histone deacetylation; • response to growth hormone; • negative regulation of G0 to G1 transition; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Fuentes: Amigo / QuickGO
Ortólogos
	5928
	19646
	ENSG00000162521
	ENSMUSG00000057236
	Q09028
	Q60972
	NM_005610; NM_001135255; NM_001135256
	NM_009030
	NP_001128727; NP_001128728; NP_005601
	NP_033056
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La proteína 4 de unión al retinoblastoma (RBBP4) es una proteína codificada en humanos por el gen RBBP4.

Esta proteína es una proteína nuclear expresada ubicuamente, perteneciente a una subfamilia altamente conservada que posee repeticiones WD. RBBP4 forma parte de complejos proteicos implicados en la acetilación de histonas y en el ensamblaje de la cromatina, como es el complejo Mi-2, que se encuentra implicado en la remodelación de la cromatina y en la represión transcripcional asociada con la deacetilación de histonas. RBBP4 también forma parte de complejos correpresores, siendo un componente integral del silenciamiento transcripcional. También es una de las muchas proteínas que se unen directamente a la proteína del retinoblastoma, y regulan la proliferación celular. Además, esta proteína está implicada en la represión transcripcional de los genes de respuesta E2F.

Interacciones

La proteína RBBP4 ha demostrado ser capaz de interaccionar con:

Significación clínica

Existe 113 enfermedades descritas que coinciden con RBBP4 (p.e.: el retinoblastoma)

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Qian YW, Wang YC, Hollingsworth RE Jr, Jones D, Ling N, Lee EY (Sep de 1993). «A retinoblastoma-binding protein related to a negative regulator of Ras in yeast». Nature 364 (6438): 648-52. PMID 8350924. doi:10.1038/364648a0.
↑ Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (Nov de 2003). «Isolation of human NURF: a regulator of Engrailed gene expression». EMBO J 22 (22): 6089-100. PMC 275440. PMID 14609955. doi:10.1093/emboj/cdg582.
↑ «Entrez Gene: RBBP4 retinoblastoma binding protein 4».
1 2 Zhang, Ying; Dufau Maria L (Jun. de 2003). «Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes». J. Steroid Biochem. Mol. Biol. (England) 85 (2-5): 401-14. ISSN 0960-0760. PMID 12943729.
1 2 Yao, Ya-Li; Yang Wen-Ming (Oct. de 2003). «The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity». J. Biol. Chem. (United States) 278 (43): 42560-8. ISSN 0021-9258. PMID 12920132. doi:10.1074/jbc.M302955200.
1 2 3 Nicolas, E; Ait-Si-Ali S, Trouche D (Aug. de 2001). «The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein». Nucleic Acids Res. (England) 29 (15): 3131-6. PMID 11470869.
↑ Grozinger, C M; Hassig C A, Schreiber S L (Apr. de 1999). «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4868-73. ISSN 0027-8424. PMID 10220385.
↑ You, A; Tong J K, Grozinger C M, Schreiber S L (Feb. de 2001). «CoREST is an integral component of the CoREST- human histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (4): 1454-8. ISSN 0027-8424. PMID 11171972. doi:10.1073/pnas.98.4.1454.
1 2 Hassig, C A; Fleischer T C, Billin A N, Schreiber S L, Ayer D E (mayo. de 1997). «Histone deacetylase activity is required for full transcriptional repression by mSin3A». Cell (UNITED STATES) 89 (3): 341-7. ISSN 0092-8674. PMID 9150133.
↑ Ng, H H; Zhang Y, Hendrich B, Johnson C A, Turner B M, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (Sep. de 1999). «MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex». Nat. Genet. (UNITED STATES) 23 (1): 58-61. ISSN 1061-4036. PMID 10471499. doi:10.1038/12659.
1 2 3 Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug. de 1999). «Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation». Genes Dev. (UNITED STATES) 13 (15): 1924-35. ISSN 0890-9369. PMID 10444591.
1 2 Zhang, Ying; Dufau Maria L (Sep. de 2002). «Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex». J. Biol. Chem. (United States) 277 (36): 33431-8. ISSN 0021-9258. PMID 12091390. doi:10.1074/jbc.M204417200.
↑ Hassig, C A; Tong J K, Fleischer T C, Owa T, Grable P G, Ayer D E, Schreiber S L (Mar. de 1998). «A role for histone deacetylase activity in HDAC1-mediated transcriptional repression». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (7): 3519-24. ISSN 0027-8424. PMID 9520398.
↑ Zhang, Y; Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (mayo. de 1997). «Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex». Cell (UNITED STATES) 89 (3): 357-64. ISSN 0092-8674. PMID 9150135.
↑ Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin (Feb. de 2003). «A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes». J. Biol. Chem. (United States) 278 (9): 7234-9. ISSN 0021-9258. PMID 12493763. doi:10.1074/jbc.M208992200.
↑ Tong, J K; Hassig C A, Schnitzler G R, Kingston R E, Schreiber S L (Oct. de 1998). «Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex». Nature (ENGLAND) 395 (6705): 917-21. ISSN 0028-0836. PMID 9804427. doi:10.1038/27699.
1 2 Zhang, Y; Sun Z W, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (Jun. de 1998). «SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex». Mol. Cell (UNITED STATES) 1 (7): 1021-31. ISSN 1097-2765. PMID 9651585.
↑ Qian, Y W; Lee E Y (Oct. de 1995). «Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast». J. Biol. Chem. (UNITED STATES) 270 (43): 25507-13. ISSN 0021-9258. PMID 7503932.
↑ Nicolas, E; Morales V, Magnaghi-Jaulin L, Harel-Bellan A, Richard-Foy H, Trouche D (Mar. de 2000). «RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein». J. Biol. Chem. (UNITED STATES) 275 (13): 9797-804. ISSN 0021-9258. PMID 10734134.
↑ Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb. de 2002). «Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)». Mol. Cell. Biol. (United States) 22 (3): 835-48. ISSN 0270-7306. PMID 11784859.
↑ Zhang, Q; Vo N, Goodman R H (Jul. de 2000). «Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB». Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970-8. ISSN 0270-7306. PMID 10866654.
↑ Feng, Qin; Cao Ru, Xia Li, Erdjument-Bromage Hediye, Tempst Paul, Zhang Yi (Jan. de 2002). «Identification and functional characterization of the p66/p68 components of the MeCP1 complex». Mol. Cell. Biol. (United States) 22 (2): 536-46. ISSN 0270-7306. PMID 11756549.
↑ Yarden, R I; Brody L C (Apr. de 1999). «BRCA1 interacts with components of the histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4983-8. ISSN 0027-8424. PMID 10220405.
↑ «MalaCards». Consultado el 21 de diciembre de 2025.
↑ «GeneCards». Consultado el 21 de diciembre de 2025.

Enlaces externos

En HomoloGene: RBBP4

En Genome:RBBP4
En MalaCards.Enfermedades que coinciden con:RBBP4
En Estudio de asociación del genoma completo (GWAS) RBBP4

Datos: Q18031054

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid8350924-3] Qian YW, Wang YC, Hollingsworth RE Jr, Jones D, Ling N, Lee EY (Sep de 1993). «A retinoblastoma-binding protein related to a negative regulator of Ras in yeast». Nature 364 (6438): 648-52. PMID 8350924. doi:10.1038/364648a0.

[pmid14609955-4] Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (Nov de 2003). «Isolation of human NURF: a regulator of Engrailed gene expression». EMBO J 22 (22): 6089-100. PMC 275440. PMID 14609955. doi:10.1093/emboj/cdg582.

[entrez-5] «Entrez Gene: RBBP4 retinoblastoma binding protein 4».

[pmid12943729-6] 1 2 Zhang, Ying; Dufau Maria L (Jun. de 2003). «Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes». J. Steroid Biochem. Mol. Biol. (England) 85 (2-5): 401-14. ISSN 0960-0760. PMID 12943729.

[pmid12920132-7] 1 2 Yao, Ya-Li; Yang Wen-Ming (Oct. de 2003). «The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity». J. Biol. Chem. (United States) 278 (43): 42560-8. ISSN 0021-9258. PMID 12920132. doi:10.1074/jbc.M302955200.

[pmid11470869-8] 1 2 3 Nicolas, E; Ait-Si-Ali S, Trouche D (Aug. de 2001). «The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein». Nucleic Acids Res. (England) 29 (15): 3131-6. PMID 11470869.

[pmid10220385-9] Grozinger, C M; Hassig C A, Schreiber S L (Apr. de 1999). «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4868-73. ISSN 0027-8424. PMID 10220385.

[pmid11171972-10] You, A; Tong J K, Grozinger C M, Schreiber S L (Feb. de 2001). «CoREST is an integral component of the CoREST- human histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (4): 1454-8. ISSN 0027-8424. PMID 11171972. doi:10.1073/pnas.98.4.1454.

[pmid9150133-11] 1 2 Hassig, C A; Fleischer T C, Billin A N, Schreiber S L, Ayer D E (mayo. de 1997). «Histone deacetylase activity is required for full transcriptional repression by mSin3A». Cell (UNITED STATES) 89 (3): 341-7. ISSN 0092-8674. PMID 9150133.

[pmid10471499-12] Ng, H H; Zhang Y, Hendrich B, Johnson C A, Turner B M, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (Sep. de 1999). «MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex». Nat. Genet. (UNITED STATES) 23 (1): 58-61. ISSN 1061-4036. PMID 10471499. doi:10.1038/12659.

[pmid10444591-13] 1 2 3 Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug. de 1999). «Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation». Genes Dev. (UNITED STATES) 13 (15): 1924-35. ISSN 0890-9369. PMID 10444591.

[pmid12091390-14] 1 2 Zhang, Ying; Dufau Maria L (Sep. de 2002). «Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex». J. Biol. Chem. (United States) 277 (36): 33431-8. ISSN 0021-9258. PMID 12091390. doi:10.1074/jbc.M204417200.

[pmid9520398-15] Hassig, C A; Tong J K, Fleischer T C, Owa T, Grable P G, Ayer D E, Schreiber S L (Mar. de 1998). «A role for histone deacetylase activity in HDAC1-mediated transcriptional repression». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (7): 3519-24. ISSN 0027-8424. PMID 9520398.

[pmid9150135-16] Zhang, Y; Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (mayo. de 1997). «Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex». Cell (UNITED STATES) 89 (3): 357-64. ISSN 0092-8674. PMID 9150135.

[pmid12493763-17] Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin (Feb. de 2003). «A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes». J. Biol. Chem. (United States) 278 (9): 7234-9. ISSN 0021-9258. PMID 12493763. doi:10.1074/jbc.M208992200.

[pmid9804427-18] Tong, J K; Hassig C A, Schnitzler G R, Kingston R E, Schreiber S L (Oct. de 1998). «Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex». Nature (ENGLAND) 395 (6705): 917-21. ISSN 0028-0836. PMID 9804427. doi:10.1038/27699.

[pmid9651585-19] 1 2 Zhang, Y; Sun Z W, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (Jun. de 1998). «SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex». Mol. Cell (UNITED STATES) 1 (7): 1021-31. ISSN 1097-2765. PMID 9651585.

[pmid7503932-20] Qian, Y W; Lee E Y (Oct. de 1995). «Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast». J. Biol. Chem. (UNITED STATES) 270 (43): 25507-13. ISSN 0021-9258. PMID 7503932.

[pmid10734134-21] Nicolas, E; Morales V, Magnaghi-Jaulin L, Harel-Bellan A, Richard-Foy H, Trouche D (Mar. de 2000). «RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein». J. Biol. Chem. (UNITED STATES) 275 (13): 9797-804. ISSN 0021-9258. PMID 10734134.

[pmid11784859-22] Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb. de 2002). «Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)». Mol. Cell. Biol. (United States) 22 (3): 835-48. ISSN 0270-7306. PMID 11784859.

[pmid10866654-23] Zhang, Q; Vo N, Goodman R H (Jul. de 2000). «Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB». Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970-8. ISSN 0270-7306. PMID 10866654.

[pmid11756549-24] Feng, Qin; Cao Ru, Xia Li, Erdjument-Bromage Hediye, Tempst Paul, Zhang Yi (Jan. de 2002). «Identification and functional characterization of the p66/p68 components of the MeCP1 complex». Mol. Cell. Biol. (United States) 22 (2): 536-46. ISSN 0270-7306. PMID 11756549.

[pmid10220405-25] Yarden, R I; Brody L C (Apr. de 1999). «BRCA1 interacts with components of the histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4983-8. ISSN 0027-8424. PMID 10220405.

[26] «MalaCards». Consultado el 21 de diciembre de 2025.

[27] «GeneCards». Consultado el 21 de diciembre de 2025.