CREBBP

Proteína de unión a CREB

Estructura tridimensional de la proteína CREBBP.
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB PDBe, RCSB
Lista de códigos PDB
1JSP , 1LIQ , 1RDT , 1WO3 , 1WO4 , 1WO5 , 1WO6 , 1WO7 , 2D82 , 2KJE , 2KWF , 2L84 , 2L85 , 2LXS , 2LXT , 2RNY , 3DWY , 3P1C , 3P1D , 3P1E , 3P1F , 3SVH , 4A9K
Estructuras enzimáticas
RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos CREBBP (HGNC: 2348) CBP; RSTS; RTS
Identificadores
externos
  • EBI: CREBBP
  • GeneCards: Gen CREBBP
  • UniProt: CREBBP
    • Bases de datos de enzimas
    IntEnz: entrada en IntEnz

    BRENDA: entrada en BRENDA

    ExPASy: NiceZime view
    KEGG: entrada en KEEG
    PRIAM: perfil PRIAM
    ExplorEnz: entrada en ExplorEnz
    MetaCyc: vía metabólica
    Número EC 2.3.1.48
    Locus Cr. 16 p13.3
    Patrón de expresión de ARNm
    ancho=250px
    ancho=250px
    Más información
    Ortólogos
    Especies
    Humano Ratón
    Entrez
    1387 12914
    Ensembl
    Véase HS Véase MM
    UniProt
    Q92793 F8VPR5
    RefSeq
    (ARNm)
    NM_001079846 NM_001025432
    RefSeq
    (proteína) NCBI
    NP_001073315 NP_001020603
    Ubicación (UCSC)
    Cr. 16:
    3.78 – 3.93 Mb         		Cr. 16:
    4.08 – 4.21 Mb
    PubMed (Búsqueda)


    Información relacionada
    Articulos relacionados Publicaciones sobre CREBBP en Google académico
    [editar datos en Wikidata]

    La lisina acetiltransferasa de unión a CREB, también conocido como CREBBP o CBP es una proteína codificada en humanos por el gen CREBBP.

    Función

    Este gen esta ubicuamente y está implicado en la co-activación transcripcional de diversos factores de transcripción. El primero fue aislado como una proteína nuclear que se une a proteínas de unión a elementos de respuesta a AMPc (CREB). Este gen es conocido por jugar un papel crítico en el desarrollo embrionario, el control de la proliferación celular y la homeostasis por medio de la reorganización de la cromatina para el reconocimiento de los factores de transcripción. Esta proteína posee una actividad histona acetiltransferasa intrínseca y actúa a su vez como andamio para estabilizar interacciones de proteínas adicionales con el complejo transcripcional. Esta proteína acetila tanto a histonas como a proteínas no histonas. Las CREBBP comparten regiones de una elevada similitud de secuencia con el bromodominio, las regiones ricas en cisteína-histidina y el dominio histona acetiltransferasa de la proteína EP300.

    Importancia clínica

    a Paciente 16 (negativo a mutaciones CREBBP); b paciente 17 (c.3715_3716delAA en el gen CREBBP); c paciente 46 (c.4627G>T en el gen CREBBP). Los rasgos faciales típicos del síndrome de Tourette son visibles en los tres pacientes. (Imagen editada del original para eliminar el exceso de espacio en blanco)

    Mutaciones en este gen son las causantes del síndrome de Rubinstein-Taybi (RTS). Se han asociado diversas traslocaciones cromosómicas de este gen con la leucemia mieloide aguda.

    Interacciones

    La proteína CREBBP ha demostrado ser capaz de interaccionar con:

    Véase también

    Referencias

    1. ↑ Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (octubre de 1993). «Phosphorylated CREB binds specifically to the nuclear protein CBP». Nature 365 (6449): 855-9. PMID 8413673. doi:10.1038/365855a0.
    2. ↑ Wydner KL, Bhattacharya S, Eckner R, Lawrence JB, Livingston DM (noviembre de 1995). «Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization». Genomics 30 (2): 395-6. PMID 8586450.
    3. 1 2 «Entrez Gene: CREBBP (CREB-binding protein)».
    4. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ (julio de 1995). «Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP». Nature 376 (6538): 348-51. PMID 7630403. doi:10.1038/376348a0.
    5. ↑ Vizmanos JL, Larráyoz MJ, Lahortiga I, Floristán F, Alvarez C, Odero MD, Novo FJ, Calasanz MJ (abril de 2003). «t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia». Genes Chromosomes Cancer 36 (4): 402-5. PMID 12619164. doi:10.1002/gcc.10174.
    6. 1 2 3 Sano, Y; Tokitou F; Dai P; Maekawa T; Yamamoto T; Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098-105. ISSN 0021-9258. PMID 9786917. doi:10.1074/jbc.273.44.29098.
    7. 1 2 Kim, J; Jia L, Stallcup M R, Coetzee G A (Feb. de 2005). «The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus». J. Mol. Endocrinol. (England) 34 (1): 107-18. ISSN 0952-5041. PMID 15691881. doi:10.1677/jme.1.01701.
    8. ↑ Frønsdal, K; Engedal N; Slagsvold T; Saatcioglu F (Nov. de 1998). «CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1». J. Biol. Chem. (UNITED STATES) 273 (48): 31853-9. ISSN 0021-9258. PMID 9822653. doi:10.1074/jbc.273.48.31853.
    9. ↑ Ishitani, Ken; Yoshida Tasuku, Kitagawa Hirochika, Ohta Hiroaki, Nozawa Shiro, Kato Shigeaki (Jul. de 2003). «p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor». Biochem. Biophys. Res. Commun. (United States) 306 (3): 660-5. ISSN 0006-291X. PMID 12810069. doi:10.1016/S0006-291X(03)01021-0.
    10. 1 2 Aarnisalo, P; Palvimo J J, Jänne O A (Mar. de 1998). «CREB-binding protein in androgen receptor-mediated signaling». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (5): 2122-7. ISSN 0027-8424. PMC 19270. PMID 9482849. doi:10.1073/pnas.95.5.2122.
    11. ↑ Pitkänen, J; Doucas V, Sternsdorf T, Nakajima T, Aratani S, Jensen K, Will H, Vähämurto P, Ollila J, Vihinen M, Scott H S, Antonarakis S E, Kudoh J, Shimizu N, Krohn K, Peterson P (Jun. de 2000). «The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein». J. Biol. Chem. (UNITED STATES) 275 (22): 16802-9. ISSN 0021-9258. PMID 10748110. doi:10.1074/jbc.M908944199.
    12. ↑ Iioka, Takashi; Furukawa Keizo, Yamaguchi Akira, Shindo Hiroyuki, Yamashita Shunichi, Tsukazaki Tomoo (Aug. de 2003). «P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain». J. Bone Miner. Res. (United States) 18 (8): 1419-29. ISSN 0884-0431. PMID 12929931. doi:10.1359/jbmr.2003.18.8.1419.
    13. 1 2 3 Fan, Saijun; Ma Yong Xian, Wang Chenguang, Yuan Ren-Qi, Meng Qinghui, Wang Ji-An, Erdos Michael, Goldberg Itzhak D, Webb Paul, Kushner Peter J, Pestell Richard G, Rosen Eliot M (Jan. de 2002). «p300 Modulates the BRCA1 inhibition of estrogen receptor activity». Cancer Res. (United States) 62 (1): 141-51. ISSN 0008-5472. PMID 11782371.
    14. ↑ Pao, G M; Janknecht R, Ruffner H, Hunter T, Verma I M (Feb. de 2000). «CBP/p300 interact with and function as transcriptional coactivators of BRCA1». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (3): 1020-5. ISSN 0027-8424. PMC 15508. PMID 10655477. doi:10.1073/pnas.97.3.1020.
    15. ↑ Chai, Y L; Cui J, Shao N, Shyam E, Reddy P, Rao V N (Jan. de 1999). «The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter». Oncogene (ENGLAND) 18 (1): 263-8. ISSN 0950-9232. PMID 9926942. doi:10.1038/sj.onc.1202323.
    16. ↑ Benezra, Miriam; Chevallier Nathalie, Morrison Debra J, MacLachlan Timothy K, El-Deiry Wafik S, Licht Jonathan D (Jul. de 2003). «BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit». J. Biol. Chem. (United States) 278 (29): 26333-41. ISSN 0021-9258. PMID 12700228. doi:10.1074/jbc.M303076200.
    17. 1 2 Neish, A S; Anderson S F, Schlegel B P, Wei W, Parvin J D (Feb. de 1998). «Factors associated with the mammalian RNA polymerase II holoenzyme». Nucleic Acids Res. (ENGLAND) 26 (3): 847-53. ISSN 0305-1048. PMC 147327. PMID 9443979. doi:10.1093/nar/26.3.847.
    18. ↑ Kawabuchi, M; Satomi Y; Takao T; Shimonishi Y; Nada S; Nagai K; Tarakhovsky A; Okada M (Apr. de 2000). «Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases». Nature (ENGLAND) 404 (6781): 999-1003. ISSN 0028-0836. PMID 10801129. doi:10.1038/35010121.
    19. 1 2 Yamaguchi, Y; Wada T; Suzuki F; Takagi T; Hasegawa J; Handa H (Aug. de 1998). «Casein kinase II interacts with the bZIP domains of several transcription factors». Nucleic Acids Res. (ENGLAND) 26 (16): 3854-61. ISSN 0305-1048. PMC 147779. PMID 9685505. doi:10.1093/nar/26.16.3854.
    20. ↑ Kovacs KA, Steinmann M; Magistretti PJ; Halfon O; Cardinaux JR (Sept. de 2003). «CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation». J Biol. Chem. (UNITED STATES) 278 (38): 36959-65. ISSN 0021-9258. PMID 12857754. doi:10.1074/jbc.M303147200.
    21. ↑ Lorentz, O; Suh E R, Taylor J K, Boudreau F, Traber P G (Mar. de 1999). «CREB-binding [corrected] protein interacts with the homeodomain protein Cdx2 and enhances transcriptional activity». J. Biol. Chem. (UNITED STATES) 274 (11): 7196-9. ISSN 0021-9258. PMID 10066780. doi:10.1074/jbc.274.11.7196.
    22. ↑ Shi, Yuling; Venkataraman Sujatha L, Dodson Gerald E, Mabb Angela M, LeBlanc Scott, Tibbetts Randal S (Apr. de 2004). «Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress». Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 5898-903. ISSN 0027-8424. PMC 395895. PMID 15073328. doi:10.1073/pnas.0307718101.
    23. ↑ Shimomura, A; Ogawa Y; Kitani T; Fujisawa H; Hagiwara M (Jul. de 1996). «Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein». J. Biol. Chem. (UNITED STATES) 271 (30): 17957-60. ISSN 0021-9258. PMID 8663317. doi:10.1074/jbc.271.30.17957.
    24. ↑ Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (Dec. de 1997). «Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions». Cell (UNITED STATES) 91 (6): 741-52. ISSN 0092-8674. PMID 9413984. doi:10.1016/S0092-8674(00)80463-8.
    25. 1 2 Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (Nov. de 2002). «Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators». J. Biol. Chem. (United States) 277 (44): 42241-8. ISSN 0021-9258. PMID 12196545. doi:10.1074/jbc.M207361200.
    26. 1 2 Giebler, H A; Lemasson I, Nyborg J K (Jul. de 2000). «p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4849-58. ISSN 0270-7306. PMC 85936. PMID 10848610. doi:10.1128/MCB.20.13.4849-4858.2000.
    27. 1 2 Zhang, Q; Vo N, Goodman R H (Jul. de 2000). «Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB». Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970-8. ISSN 0270-7306. PMC 85947. PMID 10866654. doi:10.1128/MCB.20.14.4970-4978.2000.
    28. 1 2 Ernst, P; Wang J, Huang M, Goodman R H, Korsmeyer S J (Apr. de 2001). «MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein». Mol. Cell. Biol. (United States) 21 (7): 2249-58. ISSN 0270-7306. PMC 86859. PMID 11259575. doi:10.1128/MCB.21.7.2249-2258.2001.
    29. ↑ Ledo, Fran; Kremer Leonor, Mellström Britt, Naranjo Jose R (Sep. de 2002). «Ca2+-dependent block of CREB-CBP transcription by repressor DREAM». EMBO J. (England) 21 (17): 4583-92. ISSN 0261-4189. PMC 126180. PMID 12198160. doi:10.1093/emboj/cdf440.
    30. ↑ Li, S; Aufiero B, Schiltz R L, Walsh M J (Jun. de 2000). «Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (13): 7166-71. ISSN 0027-8424. PMC 16517. PMID 10852958. doi:10.1073/pnas.130028697.
    31. 1 2 3 4 Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. de 1998). «A human RNA polymerase II complex containing factors that modify chromatin structure». Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355-63. ISSN 0270-7306. PMC 109120. PMID 9710619.
    32. ↑ Zhao, Fang; McCarrick-Walmsley Ruth, Akerblad Peter, Sigvardsson Mikael, Kadesch Tom (Jun. de 2003). «Inhibition of p300/CBP by early B-cell factor». Mol. Cell. Biol. (United States) 23 (11): 3837-46. ISSN 0270-7306. PMC 155219. PMID 12748286. doi:10.1128/MCB.23.11.3837-3846.2003.
    33. 1 2 Sheppard, H M; Harries J C, Hussain S, Bevan C, Heery D M (Jan. de 2001). «Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1». Mol. Cell. Biol. (UNITED STATES) 21 (1): 39-50. ISSN 0270-7306. PMC 86566. PMID 11113179. doi:10.1128/MCB.21.1.39-50.2001.
    34. ↑ Chakraborty, S; Senyuk V; Sitailo S; Chi Y; Nucifora G (Nov. de 2001). «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem. (United States) 276 (48): 44936-43. ISSN 0021-9258. PMID 11568182. doi:10.1074/jbc.M106733200.
    35. ↑ Nasrin, N; Ogg S, Cahill C M, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges M C (Sep. de 2000). «DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (19): 10412-7. ISSN 0027-8424. PMC 27038. PMID 10973497. doi:10.1073/pnas.190326997.
    36. ↑ Dai, P; Akimaru H; Tanaka Y; Maekawa T; Nakafuku M; Ishii S (Mar. de 1999). «Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3». J. Biol. Chem. (UNITED STATES) 274 (12): 8143-52. ISSN 0021-9258. PMID 10075717. doi:10.1074/jbc.274.12.8143.
    37. ↑ Almlöf, T; Wallberg A E, Gustafsson J A, Wright A P (Jun. de 1998). «Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors». Biochemistry (UNITED STATES) 37 (26): 9586-94. ISSN 0006-2960. PMID 9649342. doi:10.1021/bi973029x.
    38. ↑ Yoshida, E; Aratani S; Itou H; Miyagishi M; Takiguchi M; Osumu T; Murakami K; Fukamizu A (Dec. de 1997). «Functional association between CBP and HNF4 in trans-activation». Biochem. Biophys. Res. Commun. (UNITED STATES) 241 (3): 664-9. ISSN 0006-291X. PMID 9434765. doi:10.1006/bbrc.1997.7871.
    39. ↑ Dell, H; Hadzopoulou-Cladaras M (Mar. de 1999). «CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression». J. Biol. Chem. (UNITED STATES) 274 (13): 9013-21. ISSN 0021-9258. PMID 10085149. doi:10.1074/jbc.274.13.9013.
    40. ↑ Ema, M; Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y (Apr. de 1999). «Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300». EMBO J. (ENGLAND) 18 (7): 1905-14. ISSN 0261-4189. PMC 1171276. PMID 10202154. doi:10.1093/emboj/18.7.1905.
    41. ↑ Bhattacharya, S; Michels C L, Leung M K, Arany Z P, Kung A L, Livingston D M (Jan. de 1999). «Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1». Genes Dev. (UNITED STATES) 13 (1): 64-75. ISSN 0890-9369. PMC 316375. PMID 9887100. doi:10.1101/gad.13.1.64.
    42. ↑ Park, Young-Kwon; Ahn Dae-Ro, Oh Myoungsuk, Lee Taekyoung, Yang Eun Gyeong, Son Miwon, Park Hyunsung (Jul. de 2008). «Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation». Mol. Pharmacol. (United States) 74 (1): 236-45. PMID 18426857. doi:10.1124/mol.108.045278.
    43. ↑ Hofmann, Thomas G; Möller Andreas, Sirma Hüaeyin, Zentgraf Hanswalter, Taya Yoichi, Dröge Wulf, Will Hans, Schmitz M Lienhard (Jan. de 2002). «Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2». Nat. Cell Biol. (England) 4 (1): 1-10. ISSN 1465-7392. PMID 11740489. doi:10.1038/ncb715.
    44. ↑ Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (Apr. de 2000). «Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins». J. Biol. Chem. (UNITED STATES) 275 (17): 12515-20. ISSN 0021-9258. PMID 10777539. doi:10.1074/jbc.275.17.12515.
    45. ↑ Chariot, A; van Lint C, Chapelier M, Gielen J, Merville M P, Bours V (Jul. de 1999). «CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein». Oncogene (ENGLAND) 18 (27): 4007-14. ISSN 0950-9232. PMID 10435624. doi:10.1038/sj.onc.1202776.
    46. ↑ Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug. de 2002). «Human ING1 proteins differentially regulate histone acetylation». J. Biol. Chem. (United States) 277 (33): 29832-9. ISSN 0021-9258. PMID 12015309. doi:10.1074/jbc.M200197200.
    47. ↑ Hong, Wei; Resnick Ross J, Rakowski Carrie, Shalloway David, Taylor Steven J, Blobel Gerd A (Nov. de 2002). «Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68». Mol. Cancer Res. (United States) 1 (1): 48-55. ISSN 1541-7786. PMID 12496368.
    48. ↑ Song, Chao-Zhong; Keller Kimberly, Murata Ken, Asano Haruhiko, Stamatoyannopoulos George (Mar. de 2002). «Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2». J. Biol. Chem. (United States) 277 (9): 7029-36. ISSN 0021-9258. PMC 2808425. PMID 11748222. doi:10.1074/jbc.M108826200.
    49. ↑ Geiman, D E; Ton-That H, Johnson J M, Yang V W (Mar. de 2000). «Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction». Nucleic Acids Res. (ENGLAND) 28 (5): 1106-13. PMC 102607. PMID 10666450. doi:10.1093/nar/28.5.1106.
    50. ↑ Barlev, N A; Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman J L, Berger S L (Mar. de 1998). «Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1349-58. ISSN 0270-7306. PMC 108848. PMID 9488450.
    51. ↑ Chen, Qin; Dowhan Dennis H, Liang Dongcai, Moore David D, Overbeek Paul A (Jul. de 2002). «CREB-binding protein/p300 co-activation of crystallin gene expression». J. Biol. Chem. (United States) 277 (27): 24081-9. ISSN 0021-9258. PMID 11943779. doi:10.1074/jbc.M201821200.
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    53. ↑ Pearson, K L; Hunter T; Janknecht R (Dec. de 1999). «Activation of Smad1-mediated transcription by p300/CBP». Biochim. Biophys. Acta (NETHERLANDS) 1489 (2-3): 354-64. ISSN 0006-3002. PMID 10673036.
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    55. ↑ Shetty, S; Takahashi T; Matsui H; Ayengar R; Raghow R (mayo. de 1999). «Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)». Biochem. J. (ENGLAND). 339 ( Pt 3): 751-8. ISSN 0264-6021. PMC 1220213. PMID 10215616. doi:10.1042/0264-6021:3390751.
    56. 1 2 Bessa, M; Saville M K, Watson R J (Jun. de 2001). «Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator». Oncogene (England) 20 (26): 3376-86. ISSN 0950-9232. PMID 11423988. doi:10.1038/sj.onc.1204439.
    57. ↑ Polesskaya, A; Naguibneva I, Duquet A, Bengal E, Robin P, Harel-Bellan A (Aug. de 2001). «Interaction between acetylated MyoD and the bromodomain of CBP and/or p300». Mol. Cell. Biol. (United States) 21 (16): 5312-20. ISSN 0270-7306. PMC 87255. PMID 11463815. doi:10.1128/MCB.21.16.5312-5320.2001.
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