Sonic hedgehog

SHH
Saatavilla olevat rakenteet PDB Ortologiahaku: PDBe RCSB Luettelo PDB-tunnisteita 3HO5, 3M1N, 3MXW
Tunnisteet
Aliakset	SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, sonic hedgehog, Sonic hedgehog, ShhNC, sonic hedgehog signaling molecule
Muut tunnisteet	OMIM: 600725; MGI: 98297; HomoloGene: 30961; GeneCards: SHH; OMA:SHH - orthologs
Geenisijainti (Ihminen) Kromosomi Kromosomi 7 (ihminen) Lokus 7q36.3 Alku 155,799,980 bp Loppu 155,812,463 bp
Geenisijainti (Hiiri) Kromosomi Kromosomi 5 (hiiri) Lokus 5 B1|5 14.39 cM Alku 28,661,813 bp Loppu 28,672,254 bp
RNA-ilmenemisen kaava Bgee Geenisijainti (Ihminen) Geenisijainti (Hiiri) Top expressed in right lobe of liver pancreatic epithelial cell sural nerve right adrenal cortex left adrenal cortex kives mucosa of transverse colon Sappirakko Virtsarakko Spinaaliganglio Top expressed in transitional epithelium of urinary bladder hammas Poskihammas etuhampaat oral mucosa kieli Hindgut left lung lobe Selkäjänne epithelium of stomach Lisää ilmenemistietoa BioGPS Lisää ilmenemistietoa
Geenin ontologia Molekulaarinen toiminto calcium ion binding metal ion binding patched binding peptidase activity zinc ion binding laminin-1 binding glycosaminoglycan binding morphogen activity hydrolaasiaktiivisuus Proteiinisitoutuminen plasmassa endopeptidase activity Solukomponentti sytosoli endoplasmic reticulum lumen membrane cell surface membrane raft solukalvo extracellular space extracellular region Soluväliaine Biologinen prosessi positive regulation of skeletal muscle cell proliferation pattern specification process myotube differentiation mesenchymal cell proliferation male genitalia development bud outgrowth involved in lung branching limb bud formation T cell differentiation in thymus embryonic pattern specification positive regulation of skeletal muscle tissue development positive regulation of immature T cell proliferation in thymus positive regulation of kidney smooth muscle cell differentiation negative regulation of Wnt signaling pathway anatomical structure formation involved in morphogenesis ectoderm development hindgut morphogenesis spinal cord dorsal/ventral patterning formation of anatomical boundary oligodendrocyte differentiation trachea development prostate gland development negative regulation of transcription elongation from RNA polymerase II promoter limb development vasculogenesis primary prostatic bud elongation heart looping telencephalon regionalization odontogenesis of dentin-containing tooth positive regulation of mesenchymal cell proliferation Angiogeneesi positive regulation of epithelial cell proliferation involved in prostate gland development positive regulation of striated muscle cell differentiation negative regulation of proteasomal ubiquitin-dependent protein catabolic process embryonic digestive tract morphogenesis apoptotic signaling pathway inner ear development hair follicle morphogenesis cell population proliferation metanephros development lung epithelium development negative regulation of canonical Wnt signaling pathway regulation of proteolysis branching involved in salivary gland morphogenesis negative regulation of mesenchymal cell apoptotic process positive regulation of neuroblast proliferation dopaminergic neuron differentiation intermediate filament organization renal system development cell fate commitment regulation of transcription, DNA-templated positive regulation of smoothened signaling pathway androgen metabolic process kidney development lung development negative regulation of protein catabolic process thymus development embryonic organ development negative regulation of cell differentiation negative regulation of dopaminergic neuron differentiation embryonic digit morphogenesis negative regulation of alpha-beta T cell differentiation positive regulation of sclerotome development epithelial-mesenchymal cell signaling negative regulation of gene expression lymphoid progenitor cell differentiation negative thymic T cell selection positive regulation of transcription, DNA-templated positive regulation of Wnt signaling pathway ventral midline development central nervous system development development of the heart branching involved in ureteric bud morphogenesis negative regulation of T cell proliferation embryonic limb morphogenesis positive regulation of cell differentiation branching involved in prostate gland morphogenesis positive regulation of mesenchymal cell proliferation involved in ureter development establishment of cell polarity branching involved in blood vessel morphogenesis positive regulation of cerebellar granule cell precursor proliferation neuroblast proliferation pancreas development positive regulation of protein import into nucleus smoothened signaling pathway oligodendrocyte development camera-type eye development spinal cord motor neuron differentiation positive regulation of alpha-beta T cell differentiation digestive tract morphogenesis hair follicle development positive regulation of oligodendrocyte differentiation roof of mouth development left lung development striated muscle tissue development positive regulation of T cell differentiation in thymus cellular response to lithium ion embryonic foregut morphogenesis anatomical structure development thalamus development stem cell development smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation cell fate specification negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry proteolyysi embryonic skeletal system development regulation of protein localization to nucleus odontogeneesi respiratory tube development regulation of prostatic bud formation thyroid gland development negative regulation of cell migration developmental growth right lung development determination of left/right asymmetry in lateral mesoderm positive thymic T cell selection mesenchymal smoothened signaling pathway involved in prostate gland development canonical Wnt signaling pathway geeniekspression säätely osteoblast development negative regulation of cholesterol efflux dorsal/ventral neural tube patterning regulation of epithelial cell proliferation involved in prostate gland development epithelial-mesenchymal signaling involved in prostate gland development dorsal/ventral pattern formation branching morphogenesis of an epithelial tube lung lobe morphogenesis embryonic forelimb morphogenesis midbrain development skin development regulation of odontogenesis regulation of mesenchymal cell proliferation involved in prostate gland development mesenchymal cell proliferation involved in lung development positive regulation of hh target transcription factor activity prostate epithelial cord elongation metanephric mesenchymal cell proliferation involved in metanephros development endosytoosi lung morphogenesis cell development trachea morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis cell-cell signaling salivary gland cavitation hindbrain development veren hyytyminen negative regulation of kidney smooth muscle cell differentiation somite development cerebellar granule cell precursor proliferation axon guidance negative regulation of ureter smooth muscle cell differentiation positive regulation of ureter smooth muscle cell differentiation multicellular organism development animal organ formation intein-mediated protein splicing determination of left/right symmetry vasculature development positive regulation of gene expression regulation of cell population proliferation embryonic morphogenesis neural crest cell migration polarity specification of anterior/posterior axis positive regulation of cell population proliferation artery development protein localization to nucleus Bergmann glial cell differentiation forebrain development neuron fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment striated muscle cell differentiation myoblast differentiation lung-associated mesenchyme development epithelial tube branching involved in lung morphogenesis positive regulation of cell division positive regulation of transcription by RNA polymerase II anterior/posterior pattern specification embryonic hindlimb morphogenesis forebrain regionalization cell proliferation in external granule layer tracheoesophageal septum formation regulation of signaling receptor activity Lähteet:Amigo / QuickGO
Ortologia Laji Ihminen Hiiri Entrez 6469 20423 Ensembl ENSG00000164690 ENSMUSG00000002633 UniProt Q15465 Q62226 RefSeq (mRNA) NM_000193 NM_001310462 NM_009170 RefSeq (proteiini) NP_000184 NP_001297391 NP_033196 Lokaatio (UCSC) Chr 7: 155.8 – 155.81 Mb Chr 5: 28.66 – 28.67 Mb PubMed haku
Wikidata
Ihminen Wikidatassa Hiiri Wikidatassa

Sonic hedgehog (SHH, engl. Sonic hedgehog protein) on proteiini, jota koodaa samanniminen geeni (SHH, engl. sonic hedgehog signaling molecule). Se on morfogeeni, joka säätelee alkionkehitykseen liittyviä prosesseja, kuten hermoston kehittymistä. Sonic hedgehog kuuluu hedgehog-proteiiniperheeseen ja aktivoi hedgehog-signaalitietä. Geeni ja proteiini on nimetty videopelihahmo Sonic the Hedgehogin mukaan.

Geeni

SHH-geeniä esiintyy selkärankaisilla. Ihmisen geeni sijaitsee kromosomin 7 pitkässä käsivarressa, lokuksessa 7q36.3.

Tutkimushistoria

Nobel-palkitut tieteilijät Christiane Nüsslein-Volhard ja Eric Wieschaus löysivät ensimmäisen hedgehog-geenin banaanikärpäsiltä. Se sai siileihin (engl. hedgehog) viittaavan nimen, koska kärpästoukille kasvaa siilin piikkejä muistuttavia ulokkeita, jos hedgehog-geeni lakkaa mutaation takia toimimasta.

Ensimmäiset selkärankaisten hedgehog-geenit löydettiin vuonna 1993: sonic hedgehog, desert hedgehog ja indian hedgehog. Toisin kuin muut geeneistä, jotka saivat nimensä todellisilta siililajeilta, sonic hedgehog nimettiin videopelihahmo Sonic the Hedgehogin mukaan. Kaikki kolme geeniä oli alun perin tarkoitus nimetä lajien mukaan. SHH-geenin löytänyt tutkija oli kuitenkin nähnyt lehdessä Sonic the Hedgehog -videopelin mainoksen ja piti Sonic Youth -yhtyeestä, joten päätti leikillään nimetä geenin soniciksi.

Lähteet

Aiheesta muualla

• Kuvia tai muita tiedostoja aiheesta Sonic hedgehog Wikimedia Commonsissa