IGL@

IGL
식별자
다른 이름	IGL, IGL@, IGLC6, immunoglobulin lambda locus
외부 ID	GeneCards: IGL
동원체
	3535
	n/a
	n/a
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	위키데이터
인간 보기/편집

IGL@(Immunoglobulin lambda locus)은 인간 22번 염색체에 위치한 영역이며, 항체의 람다 경쇄에 대한 유전자를 포함하고 있다.

유전자

IGL@는 다음과 같은 유전자를 포함하고 있다.

IGLC@ – C
- IGLC1 – immunoglobulin lambda constant 1
- IGLC2 – immunoglobulin lambda constant 2
- IGLC3 – immunoglobulin lambda constant 3
- IGLC7 – immunoglobulin lambda constant 7
IGLJ@ – J
- IGLJn – immunoglobulin lambda joining n
- IGLJ1, IGLJ2, IGLJ3, IGLJ6, IGLJ7
IGLV@ – V
- IGLVm-n – immunoglobulin lambda variable n-m
- IGLV1-36, IGLV1-40, IGLV1-44, IGLV1-47, IGLV1-51, IGLV1-62
- IGLV2-5, IGLV2-8, IGLV2-11, IGLV2-14, IGLV2-18, IGLV2-23
- IGLV3-1, IGLV3-10, IGLV3-12, IGLV3-16, IGLV3-19, IGLV3-21, IGLV3-25, IGLV3-27
- IGLV4-3, IGLV4-60, IGLV4-69
- IGLV5-37, IGLV5-39, IGLV5-45, IGLV5-52
- IGLV6-57
- IGLV7-43
- IGLV9-49
- IGLV10-54

Ig lambda chain C regions은 인간의 IGLC2 유전자에 의해 암호화되는 단백질이다.

각주

↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
1 2 “Entrez Gene: IGL@ immunoglobulin lambda locus”.

참고 문헌

Taussig MJ (1988). “Molecular genetics of immunoglobulins.”. 《Immunology. Supplement》 1: 7–15. PMID 3133312.
Combriato G, Klobeck HG (1991). “V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism.”. 《Eur. J. Immunol.》 21 (6): 1513–22. doi:10.1002/eji.1830210627. PMID 1904362. S2CID 84668650.
Vasicek TJ, Leder P (1990). “Structure and expression of the human immunoglobulin lambda genes.”. 《J. Exp. Med.》 172 (2): 609–20. doi:10.1084/jem.172.2.609. PMC 2188323. PMID 2115572.
Emanuel BS, Cannizzaro LA, Magrath I 외 (1985). “Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.”. 《Nucleic Acids Res.》 13 (2): 381–7. doi:10.1093/nar/13.2.381. PMC 341002. PMID 3923432.
Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P (1981). “Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells.”. 《Nature》 290 (5805): 368–72. Bibcode:1981Natur.290..368H. doi:10.1038/290368a0. PMID 6783958. S2CID 4333721.
Erikson J, Martinis J, Croce CM (1982). “Assignment of the genes for human lambda immunoglobulin chains to chromosome 22.”. 《Nature》 294 (5837): 173–5. doi:10.1038/294173a0. PMID 6795508. S2CID 22056008.
McBride OW, Hieter PA, Hollis GF 외 (1982). “Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes.”. 《J. Exp. Med.》 155 (5): 1480–90. doi:10.1084/jem.155.5.1480. PMC 2186665. PMID 6802926.
Frippiat JP, Williams SC, Tomlinson IM 외 (1995). “Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2.”. 《Hum. Mol. Genet.》 4 (6): 983–91. doi:10.1093/hmg/4.6.983. PMID 7655473.
Williams SC, Frippiat JP, Tomlinson IM 외 (1997). “Sequence and evolution of the human germline V lambda repertoire.”. 《J. Mol. Biol.》 264 (2): 220–32. doi:10.1006/jmbi.1996.0636. PMID 8951372.
Kawasaki K, Minoshima S, Nakato E 외 (1997). “One-megabase sequence analysis of the human immunoglobulin lambda gene locus.”. 《Genome Res.》 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
Lefranc MP (2002). “Nomenclature of the human immunoglobulin lambda (IGL) genes.”. 《Exp. Clin. Immunogenet.》 18 (4): 242–54. doi:10.1159/000049203. PMID 11872955. S2CID 27255400.
Strausberg RL, Feingold EA, Grouse LH 외 (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. 《Proc. Natl. Acad. Sci. U.S.A.》 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Boursier L, Su W, Spencer J (2003). “Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments.”. 《Mol. Immunol.》 39 (16): 1025–34. doi:10.1016/S0161-5890(03)00033-6. PMID 12749909.
Makino DL, Henschen-Edman AH, McPherson A (2006). “Four crystal forms of a Bence-Jones protein.”. 《Acta Crystallographica Section F》 61 (Pt 1): 79–82. doi:10.1107/S1744309104028532. PMC 1952397. PMID 16508097.
Richl P, Stern U, Lipsky PE, Girschick HJ (2007). “The lambda gene immunoglobulin repertoire of human neonatal B cells.”. 《Mol. Immunol.》 45 (2): 320–7. doi:10.1016/j.molimm.2007.06.155. PMID 17675156.

[1] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[entrez-2] 1 2 “Entrez Gene: IGL@ immunoglobulin lambda locus”.

v t e 항체
종류	IgA IgD IgE IgG IgM IgY
사슬	면역글로불린 경쇄 IGK@ IGL@ surrogate IGLL1 면역글로불린 중쇄 IGH@ IGHM 중쇄 항체/IgNAR