Proteína 13 relacionada com a autofagia
A proteína 13 relacionada à autofagia, também conhecida como ATG13, é uma proteína que em humanos é codificada pelo gene KIAA0652.
O ATG13 é um fator de autofagia necessário para a formação do fagossomo. O ATG13 é um alvo da via de sinalização da quinase TOR (alvo da rapamicina em mamíferos), que regula a autofagia por meio da fosforilação do ATG13 e do ULK1, e da regulação do complexo ATG13-ULK1- RB1CC1
Referências
- ↑ «Human PubMed Reference:»
- ↑ «Entrez Gene: KIAA0652»
- ↑ Mercer CA, Kaliappan A, Dennis PB (Julho de 2009). «A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy». Autophagy. 5 (5): 649–62. PMID 19287211. doi:10.4161/auto.5.5.8249
- ↑ Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (Abril de 2009). «Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy». Mol. Biol. Cell. 20 (7): 1981–91. PMC 2663915. PMID 19211835. doi:10.1091/mbc.E08-12-1248
- ↑ Chan EY, Longatti A, McKnight NC, Tooze SA (Janeiro de 2009). «Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism». Mol. Cell. Biol. 29 (1): 157–71. PMC 2612494. PMID 18936157. doi:10.1128/MCB.01082-08
Ligações externas
Leitura adicional
- Hosokawa N, Sasaki T, Iemura S, et al. (2009). «Atg101, a novel mammalian autophagy protein interacting with Atg13». Autophagy. 5 (7): 973–9. PMID 19597335. doi:10.4161/auto.5.7.9296
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- Chan EY (2009). «mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex». Science Signaling. 2 (84): pe51. PMID 19690328. doi:10.1126/scisignal.284pe51
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
- Jung CH, Jun CB, Ro SH, et al. (2009). «ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery». Mol. Biol. Cell. 20 (7): 1992–2003. PMC 2663920. PMID 19225151. doi:10.1091/mbc.E08-12-1249
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- Chan EY, Longatti A, McKnight NC, Tooze SA (2009). «Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism». Mol. Cell. Biol. 29 (1): 157–71. PMC 2612494. PMID 18936157. doi:10.1128/MCB.01082-08
- Ganley IG, Lam du H, Wang J, et al. (2009). «ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy». J. Biol. Chem. 284 (18): 12297–305. PMC 2673298. PMID 19258318. doi:10.1074/jbc.M900573200
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