MLST8
O Subunidade LST8 do complexo alvo da rapamicina, também conhecida como subunidade LST8 do TORC ou semelhante à subunidade beta da proteína G (GβL ou Gable), é uma proteína que em humanos é codificada pelo gene MLST8 (proteína associada a MTOR, homólogo LST8). É uma subunidade de ambos, mTORC1 [en] e mTORC2, complexos que regulam o crescimento e a sobrevivência celular em resposta a sinais de nutrientes, energia, redox e hormonais. É supra-regulada em várias linhagens celulares e tecidos de câncer de cólon e próstata humanos. O knockdown de mLST8 impediu a formação de mTORC e inibiu o crescimento tumoral e a invasividade.
Referências
- ↑ «Human PubMed Reference:»
- ↑ «Entrez Gene: MTOR associated protein»
- ↑ «UniProtKB – Q9BVC4 (LST8_HUMAN)»
- ↑ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 de Abril de 2015). «mLST8 Promotes mTOR-Mediated Tumor Progression». PLOS ONE. 10 (4). Bibcode:2015PLoSO..1019015K. PMC 4408021
. PMID 25906254. doi:10.1371/journal.pone.0119015
Leitura adicional
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