MLST8

MLST8
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 4JT6, 5FLC
Identificadores
Nomes alternativos	MLST8
IDs externos	OMIM: 612190 HomoloGene: 6833 GeneCards: MLST8
Ontologia genética
Função molecular	• GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein serine/threonine kinase activator activity;
Componente celular	• citoplasma; • cariolinfa; • citosol; • TORC1 complex; • Complexo mTOR 2;
Processo biológico	• positive regulation of actin filament polymerization; • regulation of actin cytoskeleton organization; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of peptidyl-tyrosine phosphorylation; • regulation of cellular response to heat; • TORC1 signaling; • positive regulation of protein serine/threonine kinase activity; • regulation of macroautophagy; • activation of protein kinase B activity; • TOR signaling; • positive regulation of TOR signaling;
	Sources:Amigo / QuickGO
Ortólogos
	64223
	n/a
	ENSG00000167965
	n/a
	Q9BVC4
	n/a
NM_001199173; NM_001199174; NM_001199175; NM_022372; NM_001352057;
	NM_001352059; NM_001352060
	n/a
NP_001186102; NP_001186103; NP_001186104; NP_071767; NP_001338986;
	NP_001338988; NP_001338989
	n/a
	Wikidata
Ver/Editar Humano

O Subunidade LST8 do complexo alvo da rapamicina, também conhecida como subunidade LST8 do TORC ou semelhante à subunidade beta da proteína G (GβL ou Gable), é uma proteína que em humanos é codificada pelo gene MLST8 (proteína associada a MTOR, homólogo LST8). É uma subunidade de ambos, mTORC1 [en] e mTORC2, complexos que regulam o crescimento e a sobrevivência celular em resposta a sinais de nutrientes, energia, redox e hormonais. É supra-regulada em várias linhagens celulares e tecidos de câncer de cólon e próstata humanos. O knockdown de mLST8 impediu a formação de mTORC e inibiu o crescimento tumoral e a invasividade.

Referências

↑ «Human PubMed Reference:»
↑ «Entrez Gene: MTOR associated protein»
↑ «UniProtKB – Q9BVC4 (LST8_HUMAN)»
↑ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 de Abril de 2015). «mLST8 Promotes mTOR-Mediated Tumor Progression». PLOS ONE. 10 (4). Bibcode:2015PLoSO..1019015K. PMC 4408021. PMID 25906254. doi:10.1371/journal.pone.0119015

Leitura adicional

Ali SM, Sabatini DM (2005). «Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.». J. Biol. Chem. 280 (20): 19445–8. PMID 15809305. doi:10.1074/jbc.C500125200
Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C (2001). «Insulin regulation of a novel WD-40 repeat protein in adipocytes.». J. Endocrinol. 168 (2): 325–32. PMID 11182770. doi:10.1677/joe.0.1680325
Long X, Lin Y, Ortiz-Vega S, et al. (2005). «Rheb binds and regulates the mTOR kinase.». Curr. Biol. 15 (8): 702–13. Bibcode:2005CBio...15..702L. PMID 15854902. doi:10.1016/j.cub.2005.02.053
Kaizuka T, Hara T, Oshiro N, et al. (2010). «Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.». J. Biol. Chem. 285 (26): 20109–16. PMC 2888423. PMID 20427287. doi:10.1074/jbc.M110.121699
Loewith R, Jacinto E, Wullschleger S, et al. (2002). «Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.». Mol. Cell. 10 (3): 457–68. PMID 12408816. doi:10.1016/S1097-2765(02)00636-6
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). «Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.». Genome Res. 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406
Sarbassov DD, Sabatini DM (2005). «Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.». J. Biol. Chem. 280 (47): 39505–9. PMID 16183647. doi:10.1074/jbc.M506096200
Oshiro N, Yoshino K, Hidayat S, et al. (2004). «Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.». Genes Cells. 9 (4): 359–66. PMID 15066126. doi:10.1111/j.1356-9597.2004.00727.x. hdl:20.500.14094/D1002969
Inoki K, Ouyang H, Li Y, Guan KL (2005). «Signaling by target of rapamycin proteins in cell growth control.». Microbiol. Mol. Biol. Rev. 69 (1): 79–100. PMC 1082789. PMID 15755954. doi:10.1128/MMBR.69.1.79-100.2005
Behrends C, Sowa ME, Gygi SP, Harper JW (2010). «Network organization of the human autophagy system.». Nature. 466 (7302): 68–76. Bibcode:2010Natur.466...68B. PMC 2901998. PMID 20562859. doi:10.1038/nature09204
Ota T, Suzuki Y, Nishikawa T, et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
Kawai S, Enzan H, Hayashi Y, et al. (2003). «Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers.». Virchows Arch. 443 (1): 78–86. PMID 12719976. doi:10.1007/s00428-003-0804-4
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Kim DH, Sarbassov DD, Ali SM, et al. (2003). «GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.». Mol. Cell. 11 (4): 895–904. PMID 12718876. doi:10.1016/S1097-2765(03)00114-X
Jacinto E, Loewith R, Schmidt A, et al. (2004). «Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.». Nat. Cell Biol. 6 (11): 1122–8. PMID 15467718. doi:10.1038/ncb1183
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). «Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.». Science. 307 (5712): 1098–101. Bibcode:2005Sci...307.1098S. PMID 15718470. doi:10.1126/science.1106148

[1] «Human PubMed Reference:»

[entrez-2] «Entrez Gene: MTOR associated protein»

[3] «UniProtKB – Q9BVC4 (LST8_HUMAN)»

[4] Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 de Abril de 2015). «mLST8 Promotes mTOR-Mediated Tumor Progression». PLOS ONE. 10 (4). Bibcode:2015PLoSO..1019015K. PMC 4408021. PMID 25906254. doi:10.1371/journal.pone.0119015