Histidine

Histidine (symbol His or H) is an essential amino acid. It is used in the biosynthesis of proteins. It is a positively charged amino acid.

Originally it was thought essential only for infants. It has now been shown to be essential for adults also. It is encoded by the codons CAU and CAC.

Histidine was first isolated by Albrecht Kossel and Sven Gustaf Hedin in 1896. It is also a precursor to histamine, a vital inflammatory agent in immune responses.

Reflist

↑ Kopple J.D. & Swendseid M.E. 1975. Evidence that histidine is an essential amino acid in normal and chronically uremic man. Journal of Clinical Investigation. 55 (5): 881–91. doi:10.1172/JCI108016. PMC 301830. PMID 1123426
↑ Vickery, Hubert Bradford; Leavenworth, Charles S. (1928-08-01). "On the Separation of Histidine and Arginine" (PDF). Journal of Biological Chemistry. 78 (3): 627–635. doi:10.1016/S0021-9258(18)83967-9. ISSN 0021-9258

[1] Kopple J.D. & Swendseid M.E. 1975. Evidence that histidine is an essential amino acid in normal and chronically uremic man. Journal of Clinical Investigation. 55 (5): 881–91. doi:10.1172/JCI108016. PMC 301830. PMID 1123426

[2] Vickery, Hubert Bradford; Leavenworth, Charles S. (1928-08-01). "On the Separation of Histidine and Arginine" (PDF). Journal of Biological Chemistry. 78 (3): 627–635. doi:10.1016/S0021-9258(18)83967-9. ISSN 0021-9258