Secretin
Secretin is a peptide hormone that regulates water balance throughout the body. It is produced in secretory glands of the duodenum. In humans, the secretin peptide is encoded by the SCT gene, which sits on chromosome 11.
In 2007, secretin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.
Secretin was the first hormone to be identified. The crucial experiments were done at University College London in 1902. The term 'hormone' was invented in 1905.
References
- ↑ Häcki WH (1980). "Secretin". Clinics in Gastroenterology. 9 (3): 609–32. doi:10.1016/S0300-5089(21)00474-0. PMID 7000396.
- ↑ Kopin AS, Wheeler MB, Leiter AB (1990). "Secretin: structure of the precursor and tissue distribution of the mRNA". Proceedings of the National Academy of Sciences of the United States of America. 87 (6): 2299–303. Bibcode:1990PNAS...87.2299K. doi:10.1073/pnas.87.6.2299. JSTOR 2354038. PMC 53674. PMID 2315322.
- ↑ "Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption". Molecular and Cellular Biology. 27 (7): 2499–511. 2007. doi:10.1128/MCB.01088-06. PMC 1899889. PMID 17283064.
{{cite journal}}: Unknown parameter|authors=ignored (help) - ↑ "Secretin as a neurohypophysial factor regulating body water homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 106 (37): 15961–6. 2009. Bibcode:2009PNAS..10615961C. doi:10.1073/pnas.0903695106. JSTOR 40484830. PMC 2747226. PMID 19805236.
{{cite journal}}: Unknown parameter|authors=ignored (help) - ↑ Henriksen JH, Schaffalitzky de Muckadell OB (2002). "Sekretin - det første hormon" [Secretin--the first hormone]. Ugeskrift for Laeger (in Danish). 164 (3): 320–5. PMID 11816326.
- ↑ Hirst, BH (2004), "Secretin and the exposition of hormonal control", J Physiol, 560 (Pt 2): 339, doi:10.1113/jphysiol.2004.073056, PMC 1665254, PMID 15308687
