TFDP1

TFDP1
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	2AZE
Tanımlayıcılar
Başka adlar	TFDP1
Dış kimlikler	OMIM: 189902 MGI: 101934 HomoloGene: 38276 GeneCards: TFDP1
Gen yerleşimi (İnsan)
Krom.	13. Kromozom (insan)
Bitiş	113,641,473 bç
Gen ontolojisi
Moleküler işlevi	• DNA binding; • protein domain specific binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001948, GO:0016582 protein bağlanması; • GO:0001105 transcription coactivator activity; • transcription factor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Hücresel bileşeni	• transcription regulator complex; • hücre çekirdeği; • mitokondri; • Nükleoplazma; • Sitozol; • sitoplazma; • RNA polymerase II transcription regulator complex;
Biyolojik süreci	• GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • Hücre döngüsü; • cell population proliferation; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • transcription, DNA-templated; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • transcription by RNA polymerase II; • negative regulation of G0 to G1 transition; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of fat cell proliferation; • epidermis development; • anoikis; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of cell cycle; • regulation of DNA biosynthetic process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	7027
	21781
	ENSG00000198176
	ENSMUSG00000038482
	Q14186
	Q08639
	NM_007111
	NM_001291765; NM_001291766; NM_001291768; NM_009361; NM_001358991
	NP_009042
	NP_001278694; NP_001278695; NP_001278697; NP_033387; NP_001345920
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Transkripsiyon faktörü DP-1, insanlarda TFDP1 geni tarafından kodlanan bir proteindir.

İşlevi

E2F transkripsiyon faktörü ailesi, özellikle hücre döngüsünde yer alanlar olmak üzere çeşitli hücresel promotörlerin ekspresyonunu düzenler. E2F faktörleri, dimerizasyon partneri DP1 ile birlikte homodimerler veya heterodimerler halinde DNA'ya bağlanır. TFDP1, ilişkili transkripsiyon faktörlerinden oluşan bir ailenin ilk örneği olabilir.

Etkileşimleri

Ayrıca Bakınız

TFDP2

Kaynakça

1 2 3 GRCh38: Ensembl release 89: ENSG00000198176 - Ensembl, May 2017
↑ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (Nov 1993).
↑ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997).
↑ Entrez Gene: TFDP1 transcription factor Dp-1
↑ Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (Oct 1993).
↑ Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995).
↑ Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (Oct 1996).

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198176 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (Nov 1993).

[5] Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997).

[6] Entrez Gene: TFDP1 transcription factor Dp-1

[7] Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (Oct 1993).

[8] Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995).

[9] Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (Oct 1996).