The First Stage of the 2011 Copa Santander Libertadores de América football tournament ran from January 25 to February 3, 2011 (first legs: January 25–27; second legs: February 1–3).
The twelve teams were drawn into six ties on November 25, 2010, in Asunción.
Teams played in two-legged ties on a home-away basis. Each team earned 3 points for a win, 1 point for a draw, and 0 points for a loss. The following criteria were used for breaking ties on points:
The six winners advanced to the second stage to join the 26 automatic qualifiers.
Team 1 played the second leg at home.
| Teams | Scores | Tie-breakers | |||||
|---|---|---|---|---|---|---|---|
| Team 1 | Points | Team 2 | 1st leg | 2nd leg | GD | AG | Pen. |
| Deportes Tolima |
4:1 | 0–0 | 2–0 | — | — | — | |
| Chiapas |
6:0 | 2–0 | 2–0 | — | — | — | |
| Deportivo Petare |
1:4 | 0–1 | 1–1 | — | — | — | |
| Unión Española |
4:1 | 1–0 | 0–0 | — | — | — | |
| Deportivo Quito |
3:3 | 0–2 | 1–0 | −1:+1 | — | — | |
| Grêmio |
4:1 | 2–2 | 3–1 | — | — | — | |
| Corinthians | 0–0 | |
|---|---|---|
| Report |
| Deportes Tolima | 2–0 | |
|---|---|---|
| Santoya Medina |
Report |
Deportes Tolima won on points 4–1.
| Chiapas | 2–0 | |
|---|---|---|
| Pedroza Salazar |
Report |
Jaguares won on points 6–0.
| Cerro Porteño | 1–0 | |
|---|---|---|
| Nanni |
Report |
| Deportivo Petare | 1–1 | |
|---|---|---|
| Guazá |
Report | Nanni |
Cerro Porteño won on points 4–1.
| Bolívar | 0–1 | |
|---|---|---|
| Report[link removed] | Cordero |
Unión Española won on points 4–1.
| Independiente | 2–0 | |
|---|---|---|
| Defederico Rodríguez |
Report |
| Deportivo Quito | 1–0 | |
|---|---|---|
| Quiñónez |
Report |
Tied on points 3–3, Independiente won on goal difference.
| Grêmio | 3–1 | |
|---|---|---|
| André Lima Vinícius Pacheco |
Report | Alfaro |
Grêmio won on points 4–1.