| 2026 Cali Open | |
|---|---|
| Date | 19 – 25 October |
| Edition | 5th |
| Surface | Clay |
| Location | Cali, Colombia |
| 2025 Champions | |
| Singles | |
 Tomás Barrios Vera | |
| Doubles | |
 Federico Agustín Gómez /  Luis David Martínez | |
The 2026 Cali Open was a professional tennis tournament played on clay courts. It was the fifth edition of the tournament which was part of the 2026 ATP Challenger Tour. It took place in Cali, Colombia between 19 and 25 October 2026.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 BRA |
Gustavo Heide | 116 | 1 |
 COL |
Nicolás Mejía | 119 | 2 |
| ARG |
Francisco Comesaña | 125 | 3 |
 BOL |
Hugo Dellien | 128 | 4 |
| CHI |
Tomás Barrios Vera | 132 | 5 |
| BRA |
|||
 PER |
Gonzalo Bueno | 183 | 7 |
| ARG |
Facundo Mena | 197 | 8 |
The following players received wildcards into the singles main draw:
Samuel Heredia Nicolas Jarry Miguel TobónThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Diego Dedura Felipe Meligeni Alves José Pereira Franco Ribero Santiago Rodríguez Taverna Daniel SalazarThe following player received entry as a lucky loser:
vs. / vs. / 