JAML

JAML
Identifiers
Aliases	JAML, AMICA, CREA7-1, CREA7-4, Gm638, AMICA1, junction adhesion molecule like
External IDs	OMIM: 609770; MGI: 2685484; GeneCards: JAML
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MJ6, 3MJ7, 3MJ9
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,225,094 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,019,832 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; appendix; ; spleen; ; right lung; ; lymph node; ; gallbladder; ; bone marrow; ; rectum;
	Top expressed in
	granulocyte; ; duodenum; ; jejunum; ; ileum; ; colon; ; spleen; ; bone marrow; ; embryo; ; stomach; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; protein homodimerization activity; cell adhesion molecule binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; membrane; bicellular tight junction;
Biological process	immune system process; gamma-delta T cell activation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; monocyte extravasation; neutrophil extravasation; cell adhesion; positive regulation of epithelial cell proliferation involved in wound healing; leukocyte migration; neutrophil chemotaxis; regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	120425
	270152
	ENSG00000160593
	ENSMUSG00000048534
	Q86YT9
	Q80UL9
	NM_001098526; NM_001286570; NM_001286571; NM_153206
	NM_001005421
	NP_001091996; NP_001273499; NP_001273500; NP_694938
	NP_001005421
	Wikidata
View/Edit Human	View/Edit Mouse

JAML or Junctional Adhesion Molecule-Like, or AMICA1 is a JAM transmembrane protein family member. Other members of the JAM family of transmembrane proteins include JAM1, JAM2 and JAM3.

Tissue distribution

It has been shown to localize to the tight junctions of epithelial cells.

Structure

It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling.

Function

It is a known ligand of JAML is Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice).

JAML-mediated activation of CAR is required for neutrophil extravasation in addition to other leukocyte/epithelial cell interaction models.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160593 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048534 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
↑ "Entrez Gene: AMICA1 adhesion molecule, interacts with CXADR antigen 1".
↑ Zen K, Liu Y, McCall IC, Wu T, Lee W, Babbin BA, et al. (June 2005). "Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils". Molecular Biology of the Cell. 16 (6): 2694–2703. doi:10.1091/mbc.E05-01-0036. PMC 1142417. PMID 15800062.

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Moog-Lutz C, Cavé-Riant F, Guibal FC, Breau MA, Di Gioia Y, Couraud PO, et al. (November 2003). "JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells". Blood. 102 (9): 3371–3378. doi:10.1182/blood-2002-11-3462. PMID 12869515.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, et al. (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160593 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048534 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Clark_2003-5] Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

[entrez-6] "Entrez Gene: AMICA1 adhesion molecule, interacts with CXADR antigen 1".

[7] Zen K, Liu Y, McCall IC, Wu T, Lee W, Babbin BA, et al. (June 2005). "Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils". Molecular Biology of the Cell. 16 (6): 2694–2703. doi:10.1091/mbc.E05-01-0036. PMC 1142417. PMID 15800062.

JAML

Tissue distribution

Structure

Function

References

Further reading