APPBP2

APPBP2
Identifiers
Aliases	APPBP2, APP-BP2, HS.84084, PAT1, amyloid beta precursor protein binding protein 2
External IDs	OMIM: 605324; MGI: 1914134; GeneCards: APPBP2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	60,526,242 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	85,125,956 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; cerebellar vermis; ; pars compacta; ; pars reticulata; ; buccal mucosa cell; ; dorsal motor nucleus of vagus nerve; ; external globus pallidus; ; internal globus pallidus;
	Top expressed in
	Rostral migratory stream; ; vas deferens; ; Gonadal ridge; ; abdominal wall; ; umbilical cord; ; efferent ductule; ; epithelium of lens; ; migratory enteric neural crest cell; ; ventromedial nucleus; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; protein binding;
Cellular component	microtubule; cytoskeleton; cytoplasmic vesicle membrane; membrane; nucleus; microtubule associated complex; cytoplasm;
Biological process	protein transport; intracellular transport; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10513
	66884
	ENSG00000062725
	ENSMUSG00000018481
	Q92624
	Q9DAX9
	NM_001282476; NM_006380
	NM_025825
	NP_001269405; NP_006371
	NP_080101
	Wikidata
View/Edit Human	View/Edit Mouse

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.

Interactions

APPBP2 has been shown to interact with Amyloid precursor protein.{

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000062725 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018481 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Zheng P, Eastman J, Vande Pol S, Pimplikar SW (Jan 1999). "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". Proc Natl Acad Sci U S A. 95 (25): 14745–50. doi:10.1073/pnas.95.25.14745. PMC 24520. PMID 9843960.
1 2 "Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2".

External links

Human APPBP2 genome location and APPBP2 gene details page in the UCSC Genome Browser.

Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Bärlund M, Monni O, Kononen J, et al. (2000). "Multiple genes at 17q23 undergo amplification and overexpression in breast cancer". Cancer Res. 60 (19): 5340–4. PMID 11034067.
Monni O, Barlund M, Mousses S, et al. (2001). "Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5711–6. Bibcode:2001PNAS...98.5711M. doi:10.1073/pnas.091582298. PMC 33278. PMID 11331760.
Gao Y, Pimplikar SW (2002). "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14979–84. doi:10.1073/pnas.261463298. PMC 64969. PMID 11742091.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Benboudjema L, Mulvey M, Gao Y, et al. (2003). "Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides". J. Virol. 77 (17): 9192–203. doi:10.1128/JVI.77.17.9192-9203.2003. PMC 187382. PMID 12915535.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000062725 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018481 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9843960-5] 1 2 Zheng P, Eastman J, Vande Pol S, Pimplikar SW (Jan 1999). "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". Proc Natl Acad Sci U S A. 95 (25): 14745–50. doi:10.1073/pnas.95.25.14745. PMC 24520. PMID 9843960.

[entrez-6] 1 2 "Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2".

APPBP2

Interactions

References

External links

Further reading