1908-1986
In 1908, Seventh-day Adventists purchased a tuberculosis sanatorium for $9,000 that was for sale. The facility was on a former 72 acres (29 ha) farm, it was located between Estelle lake and Winyah lake in Formosa north of Orlando. In October 1908, Florida Sanatorium opened with 20 beds, two physicians, one nurse, dairy cattle and four patients.
In 1912, a building made of concrete was constructed across the farmhouse. In 1918, a third story was added to the sanitarium increasing the capacity to 60 beds. In 1925, a new wing was constructed connecting the farmhouse to the concrete building.
Beginning in the 1940s, Florida Sanatorium and Hospital began using modern medicines, molecular diagnostic and surgical procedures. On May 12, 1941, a new hospital unit opened with an operating theater, nursery and rooms for 20 patients.
In 1970, Florida Sanatorium and Hospital changed its name to Florida Hospital Orlando. In 1986, Florida Hospital Orlando bought a helicopter and it was stationed at the hospital.
2007-2019
In October 2005, the hospital had a groundbreaking for a fifteen-story tower and it topped off one month later.
The tower was being built for $260 million, it would open with 200 patient rooms and later expand to 440. One floor will be completely occupied by sixteen medical laboratories. The new larger emergency department will have seventy-two exam rooms, doubling the capacity of the emergency department. The old emergency would be renovated for radiology.
In mid July 2007, the Ginsburg Family Foundation donated $20 million to the hospital for its heart institute. In December 2008, the Ginsburg Tower opened for $255 million saving the hospital $5 million.
In late November 2015, Florida Hospital Orlando called the Florida Department of Health after a patient at the Ginsburg Tower tested positive for Legionella. They tested the water at the Ginsburg Tower, and on January 13 the tests confirmed that the bacteria was in the water. It was revealed that the bacteria that the patient had was different from the hospital.
The hospital hired Chicago-based Phigenics to flush the water system at Ginsburg Tower, which took a couple of weeks to do.
In late June 2018, Florida Hospital Orlando announced that it expanded its coronary care unit by adding eight beds.
On October 4, the hospital announced that it would expand its Cardiovascular Institute after receiving a $3 million donation from the Ginsburg Family Foundation.
On January 2, 2019, Florida Hospital Orlando changed its name to AdventHealth Orlando. On March 11, the hospital filed with Orlando to expand the emergency department at the Ginsburg Tower by 45,000 square foot (4,200 m2). Also in March, Brett Spenst became president and CEO of the hospital.
2020-present
In early October 2020, Rob Deininger was named president and CEO of AdventHealth Orlando. He took office on November 9.
During the COVID-19 pandemic the medical facility had 1,400 beds.
On October 21, a 1,800 solar panel carport was installed at AdventHealth Orlando on top of its McRae parking garage. It will charge over thirty-two electric cars, create 1.3 million kilowatts yearly, and save over $4.6 million in energy costs.
On December 16, frontline workers at the hospital received the Pfizer-BioNTech COVID-19 vaccine.
On January 1, 2021, all hospitals were required to have their chargemaster on its website by the Centers for Medicare & Medicaid Services. In early February 2023, almost all of the AdventHealth hospitals had their chargemaster on their website, including AdventHealth Orlando.
On October 12, 2021, a construction crane collapsed onto a parking garage that was being built at the AdventHealth Orlando campus. One construction worker was taken to Orlando Regional Medical Center with traumatic injuries.
On May 13, 2022, AdventHealth Orlando bought a second helicopter, they are both stationed in a 7,000 square foot (650 m2) hangar that is being leased at Orlando Executive Airport. It also renovated an adjacent 10,000 square foot (930 m2) building to be used as an office for the Flight 1 programme and a simulator for training the flight and ground rescue fleets. The renovations were finished in 2023. The reason for adding a second helicopter in 2022, Flight 1 transported 1,000 patients to AdventHealth hospitals in Florida in 2021.
In early February 2023, Loma Linda University School of Medicine partnered with AdventHealth Orlando, which will allow students to complete their third and fourth years at the hospital.
In the spring of 2024, the hospital hired Jefrë to make artwork for the parking garage of AdventHealth Innovation Tower.
In early May 2025, AdventHealth Orlando announced that it would add a fourteen-story patient and surgical tower to its campus for about $660 million. It will have twenty-four operating theaters, endoscopy, and 440 inpatient beds. It will open with 120 beds and ten operating theatres. It will have shell space for another 320 beds. The tower will increase the number of licensed beds at AdventHealth Orlando to 1,795. It was designed by HuntonBrady Architects and will be built by Brasfield & Gorrie. The hospital will be hiring more physicians and nurses, due to the growth of the Orlando metropolitan area. It will also be purchasing new technology, adding more programs and services. All total it will cost the hospital $1 billion. The hospital campus has 9,500 employees and will add about another 1,000.
In late June, Abel Biri was named president and CEO of AdventHealth Orlando, after Rob Deininger became president and CEO of AdventHealth East Florida Division.
On March 5, 2026, construction began on 2 acres (0.81 ha) adjacent to the AdventHealth Innovation Tower for a new medical office building, by demolishing retail stores and a one-story medical office building.
On March 20, demolition of a Select Specialty Hospital began as part of the expansion of the campus.
On April 20, the hospital announced that the AdventHealth Cancer Institute would be moving into the 12-story medical office building once it is completed, it will be attached to the AdventHealth Innovation Tower with a pedestrian bridge.
On September 4, construction began for the new patient and surgical tower, by demolishing older buildings at the site.
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