Alpha-glucuronidase

In enzymology, an alpha-glucuronidase (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction

an alpha-D-glucuronoside + H₂O ${\displaystyle \rightleftharpoons }$ an alcohol + D-glucuronate

Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H₂O, whereas its two products are alcohol and D-glucuronate.

This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-D-glucosiduronate glucuronohydrolase. This enzyme is also called alpha-glucosiduronase.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1GQI​, PDB: 1GQJ​, PDB: 1GQK​, PDB: 1GQL​, PDB: 1H41​, PDB: 1K9D​, PDB: 1K9E​, PDB: 1K9F​, PDB: 1L8N​, PDB: 1MQP​, PDB: 1MQQ​, PDB: 1MQR​, and PDB: 1VJT​.

See also

• Beta-glucuronidase
• Glucuronosyl-disulfoglucosamine glucuronidase
• Glycyrrhizinate beta-glucuronidase

References

• Visser, J., Kusters van Someren, M.A., Beldman, G. and Voragen, A.G.J. (Eds.), Xylans and Xylanases, Elsevier, Amsterdam, 1992, p. 213-224.
• Uchida H, Nanri T, Kawabata Y, Kusakabe I, Murakami K (1992). "Purification and characterization of intracellular alpha-glucuronidase from Aspergillus niger". Biosci. Biotechnol. Biochem. 56 (10): 1608–1615. doi:10.1271/bbb.56.1608.

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