Atrolysin C

Atrolysin C
Identifiers
EC no.3.4.24.42
CAS no.158886-17-0
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Atrolysin C (EC 3.4.24.42, Crotalus atrox metalloendopeptidase c, hemorrhagic toxin c and d) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

References

  1. ↑ Bjarnason JB, Tu AT (August 1978). "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17 (16): 3395–404. doi:10.1021/bi00609a033. PMID 210790.
  2. ↑ Fox JW, Campbell R, Beggerly L, Bjarnason JB (April 1986). "Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom". European Journal of Biochemistry. 156 (1): 65–72. doi:10.1111/j.1432-1033.1986.tb09549.x. PMID 3514216.
  3. ↑ Bjarnason JB, Fox JW (February 1987). "Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 911 (3): 356–63. doi:10.1016/0167-4838(87)90077-x. PMID 3101740.
  4. ↑ Mori N, Nikai T, Sugihara H, Tu AT (February 1987). "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom". Archives of Biochemistry and Biophysics. 253 (1): 108–21. doi:10.1016/0003-9861(87)90643-6. PMID 2949699.
  5. ↑ Shannon JD, Baramova EN, Bjarnason JB, Fox JW (July 1989). "Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin". The Journal of Biological Chemistry. 264 (20): 11575–83. doi:10.1016/S0021-9258(18)80102-8. PMID 2745407.
  6. ↑ Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S (November 1990). "Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber". Journal of Biochemistry. 108 (5): 711–9. doi:10.1093/oxfordjournals.jbchem.a123270. PMID 2081731.