ADAM8

ADAM8
Identifiers
Aliases	ADAM8, CD156, CD156a, MS2, ADAM metallopeptidase domain 8
External IDs	OMIM: 602267; MGI: 107825; GeneCards: ADAM8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DD8
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,276,868 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,572,475 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; monocyte; ; bone marrow cell; ; pancreatic ductal cell; ; periodontal fiber; ; appendix; ; upper lobe of left lung; ; right lung;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; decidua; ; trachea; ; calvaria; ; tibiofemoral joint; ; lumbar spinal ganglion; ; gastrula; ; vein; ; mesenteric lymph nodes;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein self-association; peptidase activity; protein binding; metalloendopeptidase activity; hydrolase activity; cell adhesion molecule binding; calcium ion binding; serine-type endopeptidase activity; metallopeptidase activity; zinc ion binding;
Cellular component	cytoplasm; integral component of membrane; alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; membrane; tertiary granule; integral component of plasma membrane; cell surface; specific granule; dense core granule membrane; podosome; phagolysosome; alpha9-beta1 integrin-ADAM8 complex; plasma membrane; specific granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	positive regulation of inflammatory response; extracellular matrix disassembly; proteolysis; positive regulation of cellular extravasation; positive regulation of neutrophil extravasation; positive regulation of protein processing; regulation of cell-cell adhesion; positive regulation of protein secretion; inflammatory response; cellular response to hypoxia; positive regulation of T cell migration; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; positive regulation of acute inflammatory response; cell morphogenesis; positive regulation of thymocyte apoptotic process; positive regulation of bone resorption; negative regulation of neuron apoptotic process; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of eosinophil migration; positive regulation of NF-kappaB transcription factor activity; leukocyte migration involved in inflammatory response; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling; positive regulation of T cell differentiation in thymus; lymphocyte chemotaxis; positive regulation of cell adhesion; angiogenesis; neutrophil degranulation; cell-cell adhesion; positive regulation of MAP kinase activity; positive regulation of innate immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	101
	11501
	ENSG00000151651
	ENSMUSG00000025473
	P78325
	Q05910
	NM_001109; NM_001164489; NM_001164490
	NM_001291066; NM_007403
	NP_001100; NP_001157961; NP_001157962
	NP_001277995; NP_031429
	Wikidata
View/Edit Human	View/Edit Mouse

A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.

Function

This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151651 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025473 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
1 2 "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

External links

The MEROPS online database for peptidases and their inhibitors: M12.208^{[dead link]}
ADAM8 human gene location in the UCSC Genome Browser.
ADAM8 human gene details in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151651 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025473 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9126482-5] Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.

[entrez-6] 1 2 "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pappalysin-1 Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

ADAM8

Function

See also

References

Further reading

External links