SIGLEC5

SIGLEC5
Identifiers
Aliases	SIGLEC5, CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5, sialic acid binding Ig like lectin 5
External IDs	OMIM: 604200; GeneCards: SIGLEC5
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2ZG1, 2ZG2, 2ZG3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,630,401 bp
RNA expression pattern
	Top expressed in
	blood; ; bone marrow; ; bone marrow cell; ; granulocyte; ; monocyte; ; appendix; ; lymph node; ; right lung; ; spleen; ; duodenum;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; secretory granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	cell adhesion; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8778
	n/a
	ENSG00000268500
	n/a
	O15389
	n/a
	NM_003830; NM_001384708; NM_001384709
	n/a
	NP_003821
	n/a
	Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000268500 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kim HS (Jun 1999). "Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 96. doi:10.1159/000015227. PMID 10343116. S2CID 10581090.
↑ "Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood. 92 (6): 2123–32. doi:10.1182/blood.V92.6.2123. PMID 9731071.
Patel N, Brinkman-Van der Linden EC, Altmann SW, et al. (1999). "OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily". J. Biol. Chem. 274 (32): 22729–38. doi:10.1074/jbc.274.32.22729. PMID 10428856.
Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene. 286 (2): 259–70. doi:10.1016/S0378-1119(02)00432-8. PMID 11943481.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Erickson-Miller CL, Freeman SD, Hopson CB, et al. (2003). "Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes". Exp. Hematol. 31 (5): 382–8. doi:10.1016/S0301-472X(03)00046-8. PMID 12763136.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Avril T, Freeman SD, Attrill H, et al. (2005). "Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation" (PDF). J. Biol. Chem. 280 (20): 19843–51. doi:10.1074/jbc.M502041200. PMID 15769739. S2CID 44764751.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. doi:10.1134/S0006297906050051. PMID 16732727. S2CID 11537303.
Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.
Angata T, Hayakawa T, Yamanaka M, et al. (2006). "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates". FASEB J. 20 (12): 1964–73. doi:10.1096/fj.06-5800com. PMID 17012248. S2CID 13740587.
Zhuravleva MA, Trandem K, Sun PD (2007). "Structural Implications of Siglec-5-Mediated Sialoglycan Recognition". J. Mol. Biol. 375 (2): 437–47. doi:10.1016/j.jmb.2007.10.009. PMC 2245879. PMID 18022638.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialic acid-binding Ig-like lectin 5 (SIGLEC5)

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000268500 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10343116-3] Kim HS (Jun 1999). "Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 96. doi:10.1159/000015227. PMID 10343116. S2CID 10581090.

[entrez-4] "Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons

SIGLEC5

References

Further reading

External links