CD164

CD164
Identifiers
Aliases	CD164, MGC-24, MUC-24, endolyn, DFNA66, CD164 molecule, MGC-24v
External IDs	OMIM: 603356; MGI: 1859568; GeneCards: CD164
Gene location (Human)
Chr.	Chromosome 6 (human)
End	109,382,467 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	41,407,044 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; bronchial epithelial cell; ; kidney tubule; ; secondary oocyte; ; skin of hip; ; lactiferous duct; ; rectum; ; epithelium of nasopharynx; ; glomerulus; ; skin of thigh;
	Top expressed in
	parotid gland; ; submandibular gland; ; epithelium of lens; ; Epithelium of choroid plexus; ; iris; ; retinal pigment epithelium; ; lacrimal gland; ; vestibular membrane of cochlear duct; ; cornea; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; extracellular region; lysosomal membrane; endosome; plasma membrane; lysosome; integral component of plasma membrane; endosome membrane; membrane; cytoplasmic vesicle;
Biological process	multicellular organism development; negative regulation of cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; muscle organ development; immune response; signal transduction; negative regulation of cell population proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8763
	53599
	ENSG00000135535
	ENSMUSG00000019818
	Q04900
	Q9R0L9
NM_006016; NM_001142401; NM_001142402; NM_001142403; NM_001142404;
	NM_001346500
	NM_016898
NP_001135873; NP_001135874; NP_001135875; NP_001135876; NP_001333429;
	NP_006007
	NP_058594
	Wikidata
View/Edit Human	View/Edit Mouse

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene. CD164 functions as a cell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.

A genome wide CRISPR/Cas9 screen in human A549 cells identified CD164 as an internal entry receptor for the arenavirus Lymphocytic Choriomeningitis Virus (LCMV).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135535 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019818 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood. 92 (3): 849–66. doi:10.1182/blood.V92.3.849. PMID 9680353.
↑ Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood. 92 (8): 2613–28. doi:10.1182/blood.V92.8.2613. PMID 9763543.
↑ Bakkers; et al. (2022). "CD164 is a host factor for lymphocytic choriomeningitis virus entry". Proceedings of the National Academy of Sciences. 119 (10) e2119676119. Bibcode:2022PNAS..11919676B. doi:10.1073/pnas.2119676119. PMC 8915965. PMID 35235462.

External links

CD164+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD164 genome location and CD164 gene details page in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135535 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019818 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9680353-5] 1 2 Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood. 92 (3): 849–66. doi:10.1182/blood.V92.3.849. PMID 9680353.

[pmid9763543-6] Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood. 92 (8): 2613–28. doi:10.1182/blood.V92.8.2613. PMID 9763543.

[7] Bakkers; et al. (2022). "CD164 is a host factor for lymphocytic choriomeningitis virus entry". Proceedings of the National Academy of Sciences. 119 (10) e2119676119. Bibcode:2022PNAS..11919676B. doi:10.1073/pnas.2119676119. PMC 8915965. PMID 35235462.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons

CD164

References

Further reading

External links