MST1R

MST1R
Identifiers
Aliases	MST1R, CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3, SEA
External IDs	OMIM: 600168; MGI: 99614; GeneCards: MST1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PLS, 4FWW, 4QT8
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,903,873 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,797,582 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; skin of leg; ; skin of abdomen; ; rectum; ; body of stomach; ; mucosa of ileum; ; gallbladder; ; gastric mucosa; ; upper lobe of left lung; ; testicle;
	Top expressed in
	lip; ; epithelium of stomach; ; duodenum; ; intestinal villus; ; Ileal epithelium; ; large intestine; ; colon; ; jejunum; ; mucous cell of stomach; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; macrophage colony-stimulating factor receptor activity; kinase activity; protein binding; enzyme binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; Wnt-protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; stress fiber; cell surface; vacuole; plasma membrane; receptor complex;
Biological process	defense response; positive regulation of protein kinase B signaling; positive regulation of MAP kinase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; single fertilization; protein phosphorylation; positive regulation of cell population proliferation; peptidyl-tyrosine phosphorylation; innate immune response; signal transduction; macrophage colony-stimulating factor signaling pathway; hepatocyte growth factor receptor signaling pathway; response to virus; Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4486
	19882
	ENSG00000164078
	ENSMUSG00000032584
	Q04912
	Q62190
	NM_001244937; NM_002447; NM_001318913
	NM_001287261; NM_009074
	NP_001231866; NP_001305842; NP_002438
	NP_001274190; NP_033100
	Wikidata
View/Edit Human	View/Edit Mouse

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. This protein functions as a cell membrane receptor for macrophage-stimulating protein (MST1).

MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.

Interactions

MST1R has been shown to interact with Grb2.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)