EPHA6

EPHA6
Identifiers
Aliases	EPHA6, EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066, EPH receptor A6
External IDs	OMIM: 600066; MGI: 108034; GeneCards: EPHA6
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	97,761,532 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	60,425,894 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; testicle; ; gonad; ; muscle layer of sigmoid colon; ; stromal cell of endometrium; ; Achilles tendon; ; prefrontal cortex; ; left ovary;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; lumbar spinal ganglion; ; Region I of hippocampus proper; ; hippocampus proper; ; primary visual cortex; ; superior frontal gyrus; ; zygote; ; CA3 field; ; tongue; ; cartilage of the septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; molecular function; receptor tyrosine kinase; transmembrane signaling receptor activity; transmembrane-ephrin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; nucleoplasm; cellular component; cytoplasm; neuron projection; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; peptidyl-tyrosine phosphorylation; ephrin receptor signaling pathway; biological process; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	285220
	13840
	ENSG00000080224
	ENSMUSG00000055540
	Q9UF33
	Q62413
	NM_001080448; NM_001278300; NM_001278301; NM_173655
	NM_007938
	NP_001073917; NP_001265229; NP_001265230; NP_775926
	NP_031964
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.

EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer, particularly in patients with steroid receptor negative expression and HER‑2 overexpression

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000080224 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055540 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
↑ "Entrez Gene: EPHA6 EPH receptor A6".
↑ Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018). "Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer". Oncology Letters. 15 (4): 5257–5263. doi:10.3892/ol.2018.7919. PMC 5840743. PMID 29552165.

External links

Overview of all the structural information available in the PDB for UniProt: Q62413 (Mouse Ephrin type-A receptor 6) at the PDBe-KB.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000080224 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055540 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12471243-5] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.

[entrez-6] "Entrez Gene: EPHA6 EPH receptor A6".

[7] Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018). "Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer". Oncology Letters. 15 (4): 5257–5263. doi:10.3892/ol.2018.7919. PMC 5840743. PMID 29552165.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

EPHA6

References

Further reading

External links