SIGLEC9

SIGLEC9
Identifiers
Aliases	SIGLEC9, CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9, sialic acid binding Ig like lectin 9
External IDs	OMIM: 605640; MGI: 1932475; GeneCards: SIGLEC9
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,136,651 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,309,585 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; upper lobe of left lung; ; gonad; ; right adrenal cortex; ; appendix; ; right lung; ; left adrenal gland;
	Top expressed in
	granulocyte; ; zygote; ; secondary oocyte; ; spleen; ; blood; ; embryo; ; embryo; ; right kidney; ; bone marrow; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; secretory granule membrane;
Biological process	cell surface receptor signaling pathway; cell adhesion; regulation of immune response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	27180
	83382
	ENSG00000129450
	ENSMUSG00000030474
	Q9Y336
	Q91Y57
	NM_001198558; NM_014441
	NM_031181
	NP_001185487; NP_055256
	NP_112458
	Wikidata
View/Edit Human	View/Edit Mouse

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129450 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030474 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Foussias G, Yousef GM, Diamandis EP (Aug 2000). "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)". Genomics. 67 (2): 171–8. doi:10.1006/geno.2000.6208. PMID 10903842.
↑ "Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9".

Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.
Angata T, Varki A (2000). "Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways". J. Biol. Chem. 275 (29): 22127–35. doi:10.1074/jbc.M002775200. PMID 10801860.
Zhang JQ, Nicoll G, Jones C, Crocker PR (2000). "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes". J. Biol. Chem. 275 (29): 22121–6. doi:10.1074/jbc.M002788200. PMID 10801862.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Sonnenburg JL, Altheide TK, Varki A (2004). "A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor". Glycobiology. 14 (4): 339–46. doi:10.1093/glycob/cwh039. PMID 14693915.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9". J. Biol. Chem. 279 (41): 43117–25. doi:10.1074/jbc.M403538200. PMID 15292262.
Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells". J. Immunol. 173 (11): 6841–9. doi:10.4049/jimmunol.173.11.6841. PMID 15557178.
von Gunten S, Yousefi S, Seitz M, et al. (2005). "Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment". Blood. 106 (4): 1423–31. doi:10.1182/blood-2004-10-4112. PMID 15827126.
Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. doi:10.1134/S0006297906050051. PMID 16732727. S2CID 11537303.
Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129450 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030474 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10903842-5] Foussias G, Yousef GM, Diamandis EP (Aug 2000). "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)". Genomics. 67 (2): 171–8. doi:10.1006/geno.2000.6208. PMID 10903842.

[entrez-6] "Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons

SIGLEC9

References

Further reading