SLAMF6

SLAMF6

Identifiers

SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6

External IDs

OMIM: 606446; MGI: 1353620; GeneCards: SLAMF6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2IF7

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q23.2-q23.3	Start	160,485,030 bp
Band	1q23.2-q23.3	End	160,523,262 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1 H3\|1 79.54 cM	Start	171,745,082 bp
Band	1 H3\|1 79.54 cM	End	171,780,737 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

granulocyte

lymph node

spleen

appendix

blood

bone marrow cell

superficial temporal artery

gallbladder

mucosa of transverse colon

rectum

Top expressed in

thymus

spleen

lymph node

blood

mesenteric lymph nodes

gastrula

granulocyte

submandibular gland

subcutaneous adipose tissue

embryo

More reference expression data

n/a

Gene ontology
Molecular function	protein binding
Cellular component	integral component of membrane plasma membrane extracellular exosome membrane
Biological process	natural killer cell proliferation immune system process positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity adaptive immune response T-helper 17 cell lineage commitment regulation of immune response natural killer cell differentiation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


114836


30925


ENSG00000162739


ENSMUSG00000015314


Q96DU3


Q9ET39

RefSeq (mRNA)


NM_052931 NM_001184714 NM_001184715 NM_001184716


NM_030710 NM_001347186 NM_001347187

RefSeq (protein)


NP_001171643 NP_001171644 NP_001171645 NP_443163


NP_001334115 NP_001334116 NP_109635

Location (UCSC)

Chr 1: 160.49 – 160.52 Mb

Chr 1: 171.75 – 171.78 Mb

PubMed search

View/Edit Human

View/Edit Mouse

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162739 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015314 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A (Aug 2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease". J Exp Med. 194 (3): 235–46. doi:10.1084/jem.194.3.235. PMC 2193462. PMID 11489943.
1 2 "Entrez Gene: SLAMF6 SLAM family member 6".

Further reading

Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC". Front. Biosci. 13 (13): 956–65. doi:10.2741/2735. PMID 17981603.
Hercend T, Meuer S, Brennan A, et al. (1984). "Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure". Cell. Immunol. 86 (2): 381–92. doi:10.1016/0008-8749(84)90393-9. PMID 6610481.
Kong G, Dalton M, Wardenburg JB, et al. (1996). "Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function". Mol. Cell. Biol. 16 (9): 5026–35. doi:10.1128/MCB.16.9.5026. PMC 231504. PMID 8756661.
Lee YJ, Luisiri P, Clark MR (1996). "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation". J. Immunol. 157 (9): 3828–37. doi:10.4049/jimmunol.157.9.3828. PMID 8892612.
Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Valdez PA, Wang H, Seshasayee D, et al. (2004). "NTB-A, a new activating receptor in T cells that regulates autoimmune disease". J. Biol. Chem. 279 (18): 18662–9. doi:10.1074/jbc.M312313200. PMID 14988414.
Flaig RM, Stark S, Watzl C (2004). "Cutting edge: NTB-A activates NK cells via homophilic interaction". J. Immunol. 172 (11): 6524–7. doi:10.4049/jimmunol.172.11.6524. PMID 15153464. S2CID 38642218.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stark S, Watzl C (2006). "2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells". Int. Immunol. 18 (2): 241–7. doi:10.1093/intimm/dxh358. PMID 16410313.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells". J. Immunol. 177 (5): 3170–7. doi:10.4049/jimmunol.177.5.3170. PMID 16920955.
Cao E, Ramagopal UA, Fedorov A, et al. (2006). "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family". Immunity. 25 (4): 559–70. doi:10.1016/j.immuni.2006.06.020. PMID 17045824.
Banerjee P, Feuer G, Barker E (2007). "Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells". J. Virol. 81 (18): 9707–17. doi:10.1128/JVI.00887-07. PMC 2045425. PMID 17609265.

v t e PDB gallery
2if7: Crystal Structure of NTB-A

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