CSF2RB

CSF2RB
Identifiers
Aliases	CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDs	OMIM: 138981; MGI: 1339760; GeneCards: CSF2RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C8P, 1EGJ, 1GH7, 2GYS, 4NKQ, 5DWU, 2NA9, 2NA8
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,940,439 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,189,921 bp
RNA expression pattern
	Top expressed in
	blood; ; periodontal fiber; ; decidua; ; appendix; ; epithelium of nasopharynx; ; mononuclear cell; ; monocyte; ; bone marrow; ; bone marrow cell; ; testicle;
	Top expressed in
	mesenteric lymph nodes; ; granulocyte; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; lactiferous gland; ; tibiofemoral joint; ; muscle of thigh; ; blood; ; spleen; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; cytokine receptor activity; protein tyrosine kinase activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; granulocyte macrophage colony-stimulating factor receptor complex; intracellular anatomical structure;
Biological process	respiratory gaseous exchange by respiratory system; MAPK cascade; signal transduction; response to lipopolysaccharide; peptidyl-tyrosine phosphorylation; interleukin-5-mediated signaling pathway; cellular response to interleukin-3; interleukin-3-mediated signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1439
	12984
	ENSG00000100368
	ENSMUSG00000071714
	P32927
	P26954
	NM_000395
	NM_001287389; NM_007781
	NP_000386
	NP_001274318; NP_031807
	Wikidata
View/Edit Human	View/Edit Mouse

CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100368 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071714 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

External links

Cytokine+Receptor+Common+beta+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P32927 (Human Cytokine receptor common subunit beta (CSF2RB)) at the PDBe-KB.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100368 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071714 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Woodcock_1994-5] Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
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