CD3D

CD3D
Identifiers
Aliases	CD3D, CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
External IDs	OMIM: 186790; MGI: 88331; GeneCards: CD3D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XIW
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,342,705 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,898,637 bp
RNA expression pattern
	Top expressed in
	thymus; ; granulocyte; ; lymph node; ; appendix; ; blood; ; spleen; ; epithelium of nasopharynx; ; testicle; ; mucosa of ileum; ; bone marrow;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; granulocyte; ; subcutaneous adipose tissue; ; pharynx; ; right lung lobe; ; spermatid; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; protein heterodimerization activity; transmembrane signaling receptor activity; protein homodimerization activity;
Cellular component	membrane; cytoplasm; alpha-beta T cell receptor complex; integral component of membrane; T cell receptor complex; clathrin-coated vesicle membrane; plasma membrane; external side of plasma membrane;
Biological process	positive regulation of transcription by RNA polymerase II; regulation of immune response; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection; cell surface receptor signaling pathway; membrane organization; protein homooligomerization; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	915
	12500
	ENSG00000167286
	ENSMUSG00000032094
	P04234
	P04235
	NM_001040651; NM_000732
	NM_013487
	NP_000723; NP_001035741
	NP_038515
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.

Interactions

CD3D has been shown to interact with CD8A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167286 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032094 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".
↑ Doucey MA, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). United States: 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456.

Balk SP, Polischuk JE, Probert C, et al. (1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8): 1237–41. doi:10.1093/intimm/7.8.1237. PMID 7495730.
Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685. S2CID 37846031.
Phillips JH, Hori T, Nagler A, et al. (1992). "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4): 1055–66. doi:10.1084/jem.175.4.1055. PMC 2119193. PMID 1372642.
Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4): 903–12. doi:10.1002/j.1460-2075.1991.tb08023.x. PMC 452733. PMID 1826255.
Hori T, de Waal Malefyt R, Duncan BW, et al. (1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4): 353–7. doi:10.1093/intimm/3.4.353. PMID 1831653.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1): 71–7. PMID 2111780.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083. S2CID 2180901.
Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55–65. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970.
Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10): 2953–7. doi:10.1002/j.1460-2075.1987.tb02600.x. PMC 553731. PMID 2826124.
van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011): 542–4. Bibcode:1985Natur.314..542V. doi:10.1038/314542a0. PMID 2859526. S2CID 4321989.
van den Elsen P, Georgopoulos K, Shepley BA, et al. (1986). "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9): 2944–8. Bibcode:1986PNAS...83.2944V. doi:10.1073/pnas.83.9.2944. PMC 323423. PMID 2939461.
Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. Bibcode:1987PNAS...84.7649G. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
Tunnacliffe A, Sims JE, Rabbitts TH (1986). "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6): 1245–52. doi:10.1002/j.1460-2075.1986.tb04353.x. PMC 1166934. PMID 3488209.
van den Elsen P, Shepley BA, Borst J, et al. (1985). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993): 413–8. Bibcode:1984Natur.312..413V. doi:10.1038/312413a0. PMID 6095101. S2CID 4347265.
Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.

External links

Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167286 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".

[pmid12215456-6] Doucey MA, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). United States: 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons

CD3D

Interactions

See also

References

Further reading

External links