Betamipron

Betamipron
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 3-(benzoylamino)propanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H11NO3
Molar mass193.202 g·mol−1
3D model (JSmol)
Melting point120 °C (248 °F)
  • O=C(NCCC(=O)O)c1ccccc1
  • InChI=1S/C10H11NO3/c12-9(13)6-7-11-10(14)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13) checkY
  • Key:CWXYHOHYCJXYFQ-UHFFFAOYSA-N checkY
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Betamipron (INN) or N-benzoyl-β-alanine is a chemical adjunct which is used together with panipenem in the formulation sold as Carbenin to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. Alone it has no antibacterial function.

See also

References

  1. ↑ Finch RG (2003). Antibiotic and chemotherapy: anti-infective agents and their use in therapy. Elsevier Health Sciences. pp. 269–. ISBN 978-0-443-07129-4. Retrieved 8 August 2011.
  2. ↑ Goa KL, Noble S (2003). "Panipenem/betamipron". Drugs. 63 (9): 913–25, discussion 926. doi:10.2165/00003495-200363090-00005. PMID 12678575. S2CID 263994230.
  3. ↑ Ohashi N, Uematsu T, Nagashima S, Kanamaru M, Tajima N, Togawa A, et al. (February 2005). "Pharmacokinetics of panipenem/betamipron in patients with end-stage renal disease". Journal of Infection and Chemotherapy. 11 (1): 24–31. doi:10.1007/s10156-004-0359-6. PMID 15729484.