The town is not served by any paved roads, with the Pan-American Highway to the north ending at Yaviza. It is reachable by boat up the Tuira River. Civilians are not permitted to travel further east towards Colombia.
In the early 1900s, a single-gauge railway ran to the town from the Cana gold mines. It ceased operating in 1911.
Villages within the corregimiento further up the river include Sobiaquirú.
↑Moon Central America (2016) ("Travel up the Rio Tuira beyond Boca de Cupe is considered dangerous and has been off-limits for several years. Boca de Cupe itself has a border-police post, but that doesn't necessarily make it safe.")
↑(1 March 2018). ARAP participa de Gira Interinstitucional en Sobiaquirú, provincia de Darién, La Autoridad de Recursos Acuáticos de Panamá (Translated sentence from Spanish: "The place of destination was the indigenous population of Sobiaquirú located in Alto Tuira of the Corregimiento of Boca de Cupe, province of Darién.")