CEMIP

CEMIP
Identifiers
Aliases	CEMIP, CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1
External IDs	OMIM: 608366; MGI: 2443629; GeneCards: CEMIP
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,951,776 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	83,735,710 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; trigeminal ganglion; ; stromal cell of endometrium; ; tibia; ; pericardium; ; cartilage tissue; ; olfactory bulb; ; lymph node; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	calvaria; ; vestibular sensory epithelium; ; cranial dura mater; ; stroma of bone marrow; ; body of femur; ; vestibular membrane of cochlear duct; ; stria vascularis; ; trigeminal ganglion; ; gastrula; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin heavy chain binding; ER retention sequence binding; hydrolase activity, acting on glycosyl bonds; protein binding; hyaluronic acid binding; hydrolase activity; hyalurononglucosaminidase activity;
Cellular component	cytoplasm; membrane; plasma membrane; extracellular region; endoplasmic reticulum; clathrin-coated pit; nucleus; clathrin-coated vesicle membrane; clathrin-coated endocytic vesicle;
Biological process	hyaluronan biosynthetic process; hyaluronan catabolic process; positive regulation of cell migration; positive regulation of protein kinase C activity; positive regulation of release of sequestered calcium ion into cytosol; hearing; positive regulation of peptidyl-threonine phosphorylation; metabolism; positive regulation of protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57214
	80982
	ENSG00000103888
	ENSMUSG00000052353
	Q8WUJ3
	Q8BI06
	NM_018689; NM_001293298; NM_001293304
	NM_030728
	NP_001280227; NP_001280233; NP_061159
	NP_109653
	Wikidata
View/Edit Human	View/Edit Mouse

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. Such function has also been validated in mice.

CEMIP is associated with nonsyndromic deafness, as well as a variety of cancers.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103888 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052353 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: KIAA1199 KIAA1199".
↑ Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, et al. (April 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences of the United States of America. 110 (14): 5612–5617. Bibcode:2013PNAS..110.5612Y. doi:10.1073/pnas.1215432110. PMC 3619336. PMID 23509262.
↑ Yoshida H, Nagaoka A, Nakamura S, Sugiyama Y, Okada Y, Inoue S (2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio. 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. PMC 3821019. PMID 24251095.
↑ Abe S, Usami S, Nakamura Y (November 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". Journal of Human Genetics. 48 (11): 564–570. doi:10.1007/s10038-003-0079-2. PMID 14577002.
↑ Zhang Y, Jia S, Jiang WG (April 2014). "KIAA1199 and its biological role in human cancer and cancer cells (review)". Oncology Reports. 31 (4): 1503–1508. doi:10.3892/or.2014.3038. PMID 24573670.

Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–345. doi:10.1093/dnares/6.5.337. PMID 10574462.
Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, et al. (February 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Research. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Abe S, Katagiri T, Saito-Hisaminato A, Usami S, Inoue Y, Tsunoda T, et al. (January 2003). "Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues". American Journal of Human Genetics. 72 (1): 73–82. doi:10.1086/345398. PMC 420014. PMID 12471561.
Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Letters. 580 (2): 581–584. Bibcode:2006FEBSL.580..581G. doi:10.1016/j.febslet.2005.12.076. PMID 16406369. S2CID 1013478.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000103888 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052353 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KIAA1199 KIAA1199".

[6] Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, et al. (April 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences of the United States of America. 110 (14): 5612–5617. Bibcode:2013PNAS..110.5612Y. doi:10.1073/pnas.1215432110. PMC 3619336. PMID 23509262.

[7] Yoshida H, Nagaoka A, Nakamura S, Sugiyama Y, Okada Y, Inoue S (2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio. 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. PMC 3821019. PMID 24251095.

[pmid14577002-8] Abe S, Usami S, Nakamura Y (November 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". Journal of Human Genetics. 48 (11): 564–570. doi:10.1007/s10038-003-0079-2. PMID 14577002.

[9] Zhang Y, Jia S, Jiang WG (April 2014). "KIAA1199 and its biological role in human cancer and cancer cells (review)". Oncology Reports. 31 (4): 1503–1508. doi:10.3892/or.2014.3038. PMID 24573670.

CEMIP

References

Further reading